mRNA and Protein Levels for GABA<sub>A</sub>α4, α5, β1 and GABA<sub>B</sub>R1 Receptors are Altered in Brains from Subjects with Autism

S. Hossein Fatemi; Teri J. Reutiman; Timothy D. Folsom; Robert J. Rooney; Diven H. Patel; Paul D. Thuras

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mRNA and Protein Levels for GABA_Aα4, α5, β1 and GABA_BR1 Receptors are Altered in Brains from Subjects with Autism

机译：自闭症患者大脑中GABA _{A α4，α5，β1和GABA _{B R1受体的mRNA和蛋白水平发生改变}}

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We have shown altered expression of gamma-aminobutyric acid A (GABA_A) and gamma-aminobutyric acid B (GABA_B) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA_A subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism.

机译：我们发现自闭症患者大脑中γ-氨基丁酸A（GABA _{A ）和γ-氨基丁酸B（GABA _{B ）受体的表达发生了改变。在本研究中，我们试图通过qRT-PCR验证GABBR1的蛋白质印迹数据，并扩展我们先前的工作以测量先前与自闭症（GABRα4; 3）相关的3个GABA _{A 亚基的mRNA和蛋白质水平。 GABRα5;GABRβ1）。三个GABA受体亚单位在额叶上皮（GABRα4，GABRα5，GABRβ1）中表现出mRNA和蛋白质水平的一致性，在小脑中（GABΒR1）表现出一致性。这些结果提供了自闭症中GABA能信号转导受损的进一步证据。}}}

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来源
《Journal of Autism and Developmental Disorders》 |2010年第6期|p.743-750|共8页
作者
S. Hossein Fatemi; Teri J. Reutiman; Timothy D. Folsom; Robert J. Rooney; Diven H. Patel; Paul D. Thuras;
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正文语种 eng
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GABBR1; GABRα4; GABRα5; GABRβ1; Autism; Brain;

机译：GABBR1;GABRα4;GABRα5;GABRβ1;自闭症;脑;

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1. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. [J] . Fatemi S.H., Reutiman T.J., Folsom T.D., Journal of autism and developmental disorders . 2010,第6期

机译：自闭症患者大脑中GABAAalpha4，alpha5，beta1和GABABR1受体的mRNA和蛋白质水平发生了变化。
2. Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain. [J] . Anderson JG, Fordahl SC, Cooney PT, Neurotoxicology . 2008,第6期

机译：锰暴露会改变发育中大鼠大脑中的细胞外GABA，GABA受体和转运蛋白和mRNA水平。
3. Expression of GABA_B Receptors Is Altered in Brains of Subjects with Autism [J] . S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, The Cerebellum . 2009,第1期

机译：自闭症患者大脑中GABA _{B 受体的表达发生改变}
4. Withdrawal from Chronic Ginsenoside Rb1 Treatment Alters GABAA Receptor mRNA Levels of Cultured Rat Hippocampal Neurons [C] . Yijun Tang, Zi-Li You, Wenzheng Zhang, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：退出人参皂苷Rb1慢性治疗改变了培养的大鼠海马神经元的GABAA受体mRNA水平
5. Isolation of a brain fraction enriched in GABAergic type-II postsynaptic densities. Characterization of the GABAA receptors and septin 11, two proteins enriched in this fraction [D] . Li, Xuejing. 2008

机译：分离富含加法加型-I型突触后密度的脑级分。 GABAA受体和SEDIN 11的表征，两种蛋白质富集
6. mRNA and Protein Levels for GABAAα4 α5 β1 and GABABR1 Receptors are Altered in Brains From Subjects With Autism [O] . S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, -1

机译：GABAAα4α5β1和GABABR1受体的mRNA和蛋白质水平在来自自闭症的受试者的大脑中改变
7. mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism [O] . S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, 2010

机译：GABAAα4，α5，β1和GABABR1受体的mRNA和蛋白质水平在来自自闭症的受试者的大脑中改变

mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism

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mRNA and Protein Levels for GABA_Aα4, α5, β1 and GABA_BR1 Receptors are Altered in Brains from Subjects with Autism