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Prenatal and Perinatal Risk Factors for Autism in China

机译:中国自闭症的产前和围产期危险因素

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We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old).
机译:我们对190名患有和没有自闭症的汉族儿童进行了病例对照研究,以调查中国自闭症的产前和围产期危险因素。通过公立特殊教育学校招募病例,并从同一地区(天津)的正规公立学校招募病例,并按性别和出生年份进行频率匹配。未经调整的分析确定了七个与自闭症明显相关的产前和七个围产期危险因素。在校正后的分析中,九种危险因素显示出与自闭症的显着相关性:母亲二手烟暴露,与怀孕无关的母亲慢性或急性医疗状况,母亲不愉快的情绪状态,妊娠并发症,水肿,异常胎龄(42周),食道脐带,妊娠度> 1,并且分娩时父亲年龄提前(> 30岁)。

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