Hyperserotoninemia and Altered Immunity in Autism

Nancy K. Burgess; Thayne L. Sweeten; William M. McMahon; Robert S. Fujinami

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Hyperserotoninemia and Altered Immunity in Autism

机译：高血清素血症和自闭症免疫力改变

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One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT’s role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT’s role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders.

机译：自闭症中最一致的生物学发现之一是全血血清素（5-HT）水平升高，约占1/3。在这种疾病中也通常观察到免疫异常。考虑到5-HT作为免疫调节剂的作用，本文探讨了5-HT与自闭症免疫异常之间的可能联系。关注的领域包括高血清素血症和细胞免疫功能，针对5-HT受体的自身抗体以及5-HT在自身免疫中的作用。需要进一步的研究来确定自闭症和相关疾病中神经精神病学和免疫功能障碍之间的相互作用。

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来源
《Journal of Autism and Developmental Disorders》 |2006年第5期|697-704|共8页
作者
Nancy K. Burgess; Thayne L. Sweeten; William M. McMahon; Robert S. Fujinami;
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作者单位

Department of Neurology University of Utah 30 North 1900 East 3R330 SOM Salt Lake City UT 84132-2305 USA;

Department of Neurology University of Utah 30 North 1900 East 3R330 SOM Salt Lake City UT 84132-2305 USA;

Department of Psychiatry University of Utah 30 North 1900 East 5R110 SOM Salt Lake City UT 84132 USA;

Department of Neurology University of Utah 30 North 1900 East 3R330 SOM Salt Lake City UT 84132-2305 USA;

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正文语种 eng
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关键词
Autism; Hyperserotoninemia; Immune response; Serotonin;

机译：自闭症;高血清素血症;免疫反应;5-羟色胺;

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Hyperserotoninemia and Altered Immunity in Autism

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