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首页> 外文期刊>Journal of Autism and Developmental Disorders >Double-Blind Placebo-Controlled Trial of Secretin: Effects on Aberrant Behavior in Children with Autism
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Double-Blind Placebo-Controlled Trial of Secretin: Effects on Aberrant Behavior in Children with Autism

机译：双盲安慰剂对照的促胰液素试验：对自闭症儿童异常行为的影响。

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摘要

Secretin has been proposed as a treatment alternative for autistic spectrum disorders, but empirical support is lacking. A double-blind placebo-controlled study examined the effect of a single dose of synthetic human secretin on aberrant behavior. Parent and teacher data from the Aberrant Behavior Checklist for eight male children were analyzed for reliable change in a clinical replication series. By parent and teacher report, the majority of change occurred either on the placebo trial or reflected deterioration subsequent to secretin infusion. Repeated-measures multivariate analysis of variance results were similar. Results are consistent with other studies, suggesting that secretin may not be an effective treatment option.
机译：已经提出了促胰液素作为自闭症谱系障碍的替代治疗方法，但是缺乏经验支持。一项双盲安慰剂对照研究检查了单剂量合成人促胰液素对异常行为的影响。分析了来自八个男孩的异常行为清单的父母和老师的数据，以进行临床复制系列的可靠变化。根据家长和老师的报告，大多数变化发生在安慰剂试验中或反映出促胰液素输注后的恶化。重复测量多元分析的方差结果相似。结果与其他研究一致，表明促胰液素可能不是有效的治疗选择。

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