Brief Report: Effects of Clozapine on Self-Injurious Behavior of Two Risperidone Nonresponders with Mental Retardation

Ron Hammock; William R. Levine; Stephen R. Schroeder

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Brief Report: Effects of Clozapine on Self-Injurious Behavior of Two Risperidone Nonresponders with Mental Retardation

机译：简要报告：氯氮平对两种利培酮无反应者的心理伤害自伤害行为的影响

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A typical antipsychotic medications for self-injurious behavior (SIB), aggression, and destruction among people with mental retardation and development disabilities are becoming increasingly accepted. Most studies are on risperidone and fewer have been conducted on clozapine. The present single-blind study reports marked reductions in SIB and aggression of two persons with profound mental retardation who were nonresponsive to all other behavioral and psychopharmacological interventions, including risperidone. The most effective dose was 200 mg/day. Side effects were mild and the drug was tolerated well.

机译：在智力低下和发育障碍的人中，用于自我伤害行为（SIB），攻击性和破坏性的典型抗精神病药物正日益被接受。大多数研究是关于利培酮的，而氯氮平的研究较少。目前的单盲研究报告显示，两个对各种其他行为和心理药物干预措施（包括利培酮）无反应的重度智力低下者的SIB降低，且攻击性降低。最有效的剂量是200毫克/天。副作用轻微，药物耐受性良好。

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来源
《Journal of Autism and Developmental Disorders》 |2001年第1期|109-113|共5页
作者
Ron Hammock; William R. Levine; Stephen R. Schroeder;
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作者单位

University of Kansas;

Creative Community Living Inc.;

University of Kansas;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Self-injurious behavior; risperidone; clozapine;

机译：自残行为;利培酮;氯氮平;

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5. The use of vibration to decrease self-injurious and self-stimulatory behavior in persons with severe or profound mental retardation [D] . Wexler, Lawrence J. 1996

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6. Rate-decreasing effects of the atypical neuroleptic risperidone attenuated by conditions of reinforcement in a woman with mental retardation. [O] . J Helen Yoo, Dean C Williams, Deborah A Napolitano, 2003

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Brief Report: Effects of Clozapine on Self-Injurious Behavior of Two Risperidone Nonresponders with Mental Retardation

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