GH101 FAMILY OF GLYCOSIDE HYDROLASES: SUBFAMILY STRUCTURE AND EVOLUTIONARY CONNECTIONS WITH OTHER FAMILIES

DANIIL G. NAUMOFF

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GH101 FAMILY OF GLYCOSIDE HYDROLASES: SUBFAMILY STRUCTURE AND EVOLUTIONARY CONNECTIONS WITH OTHER FAMILIES

机译：GH101糖苷水合物家族：子家族的结构以及与其他家族的进化联系

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The GH101 family is composed of endo-α-N-acetylgalactosaminidases and their homologues. Pairwise sequence comparison and phylogenetic analysis allowed us to distinguish five to six subfamilies in this family. Diverse domain structures were found among the family members. Usually they have five irreplaceable and some optional domains. Iterative screening of the protein database revealed an evolutionary relationship of the GH101 catalytic domain with glycoside hydrolase domains from GH13, GH31, and GH70 families. Among other homologous proteins we have found representatives of COG1649, as well as members of four new families of predicted glycoside hydrolases (GHL1-GHL4).

机译：GH101家族由内α-N-乙酰基半乳糖苷酶及其同源物组成。成对序列比较和系统发育分析使我们能够区分该家族中的五到六个亚科。在家庭成员中发现了多种域结构。通常，它们具有五个不可替代的域和一些可选域。蛋白质数据库的迭代筛选显示GH101催化结构域与GH13，GH31和GH70家族的糖苷水解酶结构域之间的进化关系。在其他同源蛋白中，我们发现了COG1649的代表，以及四个新的预测糖苷水解酶家族（GHL1-GHL4）的成员。

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来源
《Journal of Bioinformatics and Computational Biology》 |2010年第3期|p.437-451|共15页
作者
DANIIL G. NAUMOFF;
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作者单位

Laboratory of Bioinformatics, State Institute for Genetics and Selection of Industrial Microorganisms, I-Dorozhny Proezd, 1, Moscow 117545, Russia;

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正文语种 eng
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Sequence-based classification of proteins; protein phylogeny; protein family; glycoside hydrolases; GH101; GH13; TIM-barrel fold; CAZy; PSI-BLAST; PSI Protein Classifier; endo-α-N-acetylgalactosaminidase; gene annotation.;

机译：基于序列的蛋白质分类;蛋白质系统发育蛋白质家族;糖苷水解酶;GH101;GH13;TIM桶褶皱;CAZy;PSI-BLAST;PSI蛋白质分类器内α-N-乙酰半乳糖苷酶;基因注释。;

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1. GH101 family of glycoside hydrolases: Subfamily structure and evolutionary connections with other families [J] . Naumoff D.G. Journal of Bioinformatics and Computational Biology . 2010,第3期

机译：GH101糖苷水解酶家族：亚家族结构和与其他家族的进化联系
2. A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16) [J] . Alexander Holm Viborg, Nicolas Terrapon, Vincent Lombard, The Journal of biological chemistry . 2019,第44期

机译：进化上多样化的糖苷水解酶家族16（GH16）的亚家族路线图
3. GH10 Family of Glycoside Hydrolases: Structure and Evolutionary Connections [J] . Naumoff D. G. Molecular Biology . 2016,第1期

机译：GH10糖苷水解酶家族：结构与进化联系
4. REFINING AND MINING THE PHYLOGENY OF GLYCOSIDE HYDROLASE FAMILY 74 VIA STRUCTURE-FUNCTION ANALYSIS [C] . G. Arnal, J. Asohan, B. Henrissat, Enzyme Engineering Conference . 2018

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6. A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16) [O] . Alexander Holm Viborg, Nicolas Terrapon, Vincent Lombard, 2019

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7. The 1.62 Å structure of Thermoascus aurantiacus endoglucanase: completing the structural picture of subfamilies in glycoside hydrolase family 5 [O] . Lo Leggio Leila, Larsen Sine 2002

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GH101 FAMILY OF GLYCOSIDE HYDROLASES: SUBFAMILY STRUCTURE AND EVOLUTIONARY CONNECTIONS WITH OTHER FAMILIES

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