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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >SNPS IN THE HIV-1 TATA BOX AND THE AIDS PANDEMIC
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SNPS IN THE HIV-1 TATA BOX AND THE AIDS PANDEMIC

机译：HIV-1塔塔盒和艾滋病大流行中的SNPS

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摘要

Evolutionary trends have been examined in 146 HIV-1 forms (2662 copies, 2311 isolates) polymorphic for the TATA box using the "DNA sequence→affinity for TBP" regression (TBP is the TATA binding protein). As a result, a statistically significant excess of low-affinity TATA box HIV-1 variants corresponding to a low level of both basal and TAT-dependent expression and, consequently, slow replication of HIV-1 have been detected. A detailed analysis revealed that the excess of slowly replicating HIV-1 is associated with the subtype E-associated TATA box core sequence "CATAAAA". Principal Component Analysis performed on 2662 HIV-1 TATA box copies in 70 countries revealed the presence of two principal components, PC1 (75.7% of the variance) and PC2 (23.3% of the variance). They indicate that each of these countries is specifically associated with one of the following trends in HIV-1 evolution: neutral drift around the normal TATA box; neutral drift around the slowly replicatingTATA box core sequence (phylogenetic inertia); an adaptive increase in the frequency of the slowly replicating form.
机译：已使用“ DNA序列→TBP亲和力”回归（TBP是TATA结合蛋白）对TATA盒的146种HIV-1形式（2662拷贝，2311个分离株）多态性进行了研究。结果，已经检测到统计学上显着过量的低亲和力TATA盒HIV-1变体，其对应于基础和TAT依赖性表达的低水平，因此，HIV-1的缓慢复制。详尽的分析表明，缓慢复制的HIV-1过多与亚型E相关的TATA盒核心序列“ CATAAAA”有关。在70个国家/地区对2662个HIV-1 TATA盒拷贝进行的主成分分析显示，存在两个主成分，PC1（变异的75.7％）和PC2（变异的23.3％）。他们指出，这些国家中的每一个都与下列HIV-1演变趋势之一相关：正常TATA盒周围的中性漂移；缓慢复制的TATA盒核心序列周围的中性漂移（系统发生惯性）;缓慢复制形式的频率的自适应增加。

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