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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >DYNAMIC EQUILIBRIUM OF RECONSTITUTING HEMATOPOIETIC STEM CELL POPULATIONS
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DYNAMIC EQUILIBRIUM OF RECONSTITUTING HEMATOPOIETIC STEM CELL POPULATIONS

机译：重组造血干细胞群体的动态平衡

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摘要

Clonal dominance in hematopoietic stem cell populations is an important question of interest but not one we can directly answer. Any estimates are based on indirect measurement. For marked populations, we can equate empirical and theoretical moments for binomial sampling, in particular we can use the well-known formula for the sampling variation of a binomial proportion. The empirical variance itself cannot always be reliably estimated and some caution is needed. We describe the difficulties here and identify ready solutions which only require appropriate use of variance-stabilizing transformations. From these we obtain estimators for the steady state, or dynamic equilibrium, of the number of hematopoietic stem cells involved in repopulating the marrow. The calculations themselves are not too involved. We give the distribution theory for the estimator as well as simple approximations for practical application. As an illustration, we rework on data recently gathered to address the question as to whether or not reconstitution of marrow grafts in the clinical setting might be considered to be oligoclonal.
机译：造血干细胞群体的克隆优势是一个重要的重要问题，但我们不能直接回答。任何估计均基于间接测量。对于标记种群，我们可以将经验矩和理论矩等价用于二项式采样，特别是可以使用众所周知的公式来计算二项式比例的采样变化。经验方差本身不能总是可靠地估计，因此需要谨慎。我们在这里描述困难并确定仅需要适当使用方差稳定化变换的现成解决方案。从这些中，我们获得了参与骨髓重建的造血干细胞数量的稳态或动态平衡的估计量。计算本身并不涉及太多。我们给出了估计量的分布理论以及实际应用中的简单近似值。作为说明，我们对最近收集的数据进行了重新处理，以解决有关在临床环境中重建骨髓移植物是否被认为是寡克隆的问题。

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