ADEPTS: ADVANCED PEPTIDE DE NOVO SEQUENCING WITH A PAIR OF TANDEM MASS SPECTRA

LIN HE∗ and BIN MA†

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ADEPTS: ADVANCED PEPTIDE DE NOVO SEQUENCING WITH A PAIR OF TANDEM MASS SPECTRA

机译：接受：一对串联质谱的先进肽从头测序

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De novo sequencing is an important task in proteomics to identify novel peptide sequences. Traditionally, only one MS/MS spectrum is used for the sequencing of a peptide; however, the use of multiple spectra of the same peptide with different types of fragmentation has the potential to significantly increase the accuracy and practicality of de novo sequencing. Research into the use of multiple spectra is in a nascent stage. We propose a general framework to combine the two different types of MS/MS data. Experiments demonstrate that our method significantly improves the de novo sequencing of existing software.

机译：从头测序是蛋白质组学中鉴定新肽序列的重要任务。传统上，仅使用一个MS / MS谱图对肽进行测序。但是，使用具有不同片段类型的同一肽段的多个光谱可能会显着提高从头测序的准确性和实用性。对使用多种光谱的研究尚处于起步阶段。我们提出了一个通用框架来组合两种不同类型的MS / MS数据。实验表明，我们的方法大大改善了现有软件的从头排序。

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来源
《Journal of Bioinformatics and Computational Biology》 |2010年第6期|p.981-994|共14页
作者
LIN HE∗ and BIN MA†;
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David R. Cheriton School of Computer ScienceUniversity of Waterloo, Waterloo, Ontario N2L 3G1, Canada∗l22he@uwaterloo.ca†binma@uwaterloo.ca;

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原文格式 PDF
正文语种 eng
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关键词
Peptide de novo sequencing; tandem mass spectrometry; CID; ETD.;

机译：肽从头测序;串联质谱CID;ETD。;

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专利

1. Adepts: Advanced peptide de novo sequencing with a pair of tandem mass spectra [J] . He L., Ma B. Journal of Bioinformatics and Computational Biology . 2010,第6期

机译：专家：具有一对串联质谱的先进的从头测序
2. Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo sequencing [J] . Brownstein Naomi C., Guan Xiaoyan, Mao Yuan, Rapid Communications in Mass Spectrometry: RCM . 2015,第7期

机译：成对的单残基转座的Lys-N和Lys-C消化可无标记地鉴定N末端和C末端MS / MS肽产物离子：超高分辨率傅里叶变换离子回旋共振质谱和串联质谱从头开始排序
3. Spectral dictionaries: Integrating de novo peptide sequencing with database search of tandem mass spectra. [J] . Kim S, Gupta N, Bandeira N, Molecular & cellular proteomics: MCP . 2009,第1期

机译：光谱词典：将从头肽测序与串联质谱数据库搜索集成在一起。
4. NovoPair: De novo peptide sequencing for tandem mass spectra pair [C] . Yan Yan, Kusalik Anthony J., Fang-Xiang Wu IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：NovoPair：串联质谱对的从头肽测序
5. Spectral networks algorithms for de novo interpretation of tandem mass spectra. [D] . Bandeira, Nuno Filipe Cabrita. 2007

机译：从头解释串联质谱的光谱网络算法。
6. Spectral Profiles, a Novel Representation of Tandem Mass Spectra and Their Applications for de Novo Peptide Sequencing and Identification [O] . Sangtae Kim, Nuno Bandeira, Pavel A. Pevzner 2017

机译：光谱图谱，串联质谱的一种新颖表示形式及其在从头肽测序和鉴定中的应用
7. Spectral Profiles, a Novel Representation of Tandem Mass Spectra and Their Applications for de Novo Peptide Sequencing and Identification*S⃞ [O] . Kim, Sangtae, Bandeira, Nuno, Pevzner, Pavel A. 2009

机译：光谱图谱，串联质谱的新代表及其在从头肽测序和鉴定中的应用*S⃞

ADEPTS: ADVANCED PEPTIDE DE NOVO SEQUENCING WITH A PAIR OF TANDEM MASS SPECTRA

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