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首页> 外文期刊>Journal of Biological Physics >Neuromodulatory Control of Neocortical Microcircuits with Activity-Dependent Short-Term Synaptic Depression
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Neuromodulatory Control of Neocortical Microcircuits with Activity-Dependent Short-Term Synaptic Depression

机译：具有活动依赖的短期突触抑制的新皮质微电路的神经调节控制。

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摘要

A biophysical model of a neocortical microcircuit system is formulated and employed in studies of neuromodulatory control of dynamics and function. The model is based on recent observations of reciprocal connections between pyramidal cells and inhibitory interneurons and incorporates a new type of activity-dependent short-term depression of synaptic couplings recently observed. The model neurons are of a low-dimensional type also accounting for neuronal adaptation, i.e. the coupling between neuronal activity and excitability, which can be regulated by various neuromodulators in the brain. The results obtained demonstrate a capacity for neuromodulatory control of dynamical mode linked to functional mode. The functional aspects considered refer to the observed resolution of multiple objects in working memory as well as the binding of different features for the perception of an object. The effects of neuromodulators displayed by the model are in accordance with many observations on neuromodulatory influence on cognitive functions and brain disorders.
机译：制定了新皮层微电路系统的生物物理模型，并将其用于动力学和功能的神经调节控制的研究。该模型基于对锥体细胞和抑制性中间神经元之间的相互联系的最新观察，并结合了最近观察到的新型的依赖于活性的突触耦合短期抑制。模型神经元是低维类型，也说明了神经元适应性，即神经元活动性和兴奋性之间的耦合，其可以由大脑中的各种神经调节剂调节。获得的结果证明了对与功能模式相关的动态模式进行神经调节控制的能力。所考虑的功能方面是指在工作内存中观察到的多个对象的分辨率，以及对对象感知的不同特征的绑定。该模型显示的神经调节剂的作用与神经调节作用对认知功能和脑部疾病的许多观察结果一致。

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