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Combination of virtual point detector concept and fluence compensation in acoustic resolution photoacoustic microscopy

机译:虚分辨率光声显微镜中虚拟点检测器概念与注量补偿的结合

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摘要

We propose a hybrid approach to image enhancement in acoustic resolution photoacoustic microscopy. The developed technique is based on compensation for nonuniform spatial sensitivity of the optoacoustic (OA) system in both optical and acoustic domains. Spatial distribution of optical fluence is derived from full three-dimensional Monte Carlo simulations accounting for conical geometry of tissue laser illumination at the wavelength of 532 nm. Approximate nonuniform spatial response of acoustic detector with numerical aperture of 0.6 is derived from the two-dimensional k-Wave modeling. Application of the developed technique allows to improve the spatial resolution and to balance in-depth signal-level distribution in OA images of phantom and in-vivo objects.
机译:我们提出了一种在声音分辨率光声显微镜中增强图像的混合方法。所开发的技术基于对光学和声学领域中光声(OA)系统的非均匀空间灵敏度的补偿。光通量的空间分布是从完整的三维蒙特卡洛模拟得出的,该模拟考虑了波长为532 nm的组织激光照射的锥形几何形状。从二维k-Wave模型推导了数值孔径为0.6的声检测器的近似非均匀空间响应。所开发技术的应用可以提高空间分辨率,并平衡幻影对象和体内对象的OA图像中的深度信号级别分布。

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