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首页> 外文期刊>Journal of biomedical optics >Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report
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Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report

机译：基于高级数据分析的用于免费组织转移监测的普及型可穿戴设备：临床研究报告

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摘要

Free tissue transfer (FTT) surgery for breast reconstruction following mastectomy has become a routine operation with high success rates. Although failure is low, it can have a devastating impact on patient recovery, prognosis, and psychological well-being. Continuous and objective monitoring of tissue oxygen saturation (StO_2) has been shown to reduce failure rates through rapid detection time of postoperative vascular complications. We have developed a pervasive wearable wireless device that employs near-infrared spectroscopy (NIRS) to continuously monitor FTT via StO_2 measurement. Previously tested on different models, the results of a clinical study are introduced. Our goal for the study is to demonstrate that the developed device can reliably detect StO_2 variations in a clinical setting: 14 patients were recruited. Advanced data analysis was performed on the StO_2 variations, the relative StO_2 gradient change, and the classification of the StO_2 within different clusters of blood occlusion level (from 0% to 100% at 25% step) based on previous studies made on a vascular phantom and animals. The outcomes of the clinical study concur with previous experimental results and the expected biological responses. This suggests that the device is able to correctly detect perfusion changes and provide real-time assessment on the viability of the FTT in a clinical setting.
机译：乳房切除术后用于乳房重建的免费组织转移（FTT）手术已成为常规手术，成功率很高。尽管失败率很低，但它可能对患者的康复，预后和心理健康产生毁灭性影响。连续和客观地监测组织氧饱和度（StO_2）已被证明可通过快速检测术后血管并发症来降低失败率。我们已经开发出一种普及型可穿戴无线设备，该设备采用近红外光谱（NIRS）来通过StO_2测量连续监视FTT。先前已在不同模型上进行了测试，并介绍了临床研究的结果。我们的研究目标是证明开发出的装置可在临床环境中可靠地检测StO_2的变化：招募了14名患者。根据以前对血管模型的研究，对StO_2的变化，相对的StO_2梯度变化以及不同的血液阻塞水平簇（从0％到100％，25％步长）内的StO_2进行了高级数据分析和动物。临床研究的结果与以前的实验结果和预期的生物学反应一致。这表明该设备能够正确检测灌注变化，并在临床环境中提供FTT生存能力的实时评估。

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  • 来源
    《Journal of biomedical optics》 |2019年第6期|067001.1-067001.8|共8页
  • 作者

    Melissa Berthelot; Francis Patrick Henry; Judith Hunter; Daniel Leff; Simon Wood; Navid Jallali; Elizabeth Dex; Ladislava Lysakova; Benny Lo; Guang-Zhong Yang;

  • 作者单位

    lmperial College London, The Hamlyn Centre, South Kensington Campus, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College Healthcare NHS Trust London, Charing Cross Hospital, London, United Kingdom;

    lmperial College London, The Hamlyn Centre, South Kensington Campus, London, United Kingdom;

    lmperial College London, The Hamlyn Centre, South Kensington Campus, London, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    spectroscopy; near-infrared spectroscopy; free tissue transfer; breast reconstruction surgery; wearable device; internet of things;

    机译：光谱学近红外光谱自由组织转移;乳房再造手术;可穿戴设备物联网;

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