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首页> 外文期刊>Journal of biomedical optics >Porcine skin damage thresholds and histological damage characteristics from 1319-nm laser radiation
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Porcine skin damage thresholds and histological damage characteristics from 1319-nm laser radiation

机译：猪皮肤损伤阈值和1319 nm激光辐射的组织学损伤特征

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摘要

There is an increasing use of near-infrared lasers in biomedical applications operating in the spectrum between 1300 and 1400 nm. To corroborate and expand the existing safety data for skin exposure to lasers in this wavelength region, the in-vivo ED_(50) damage thresholds were determined in Guizhou miniature pigs for 1319-nm laser radiation. Exposure durations of 0.4,1.0, and 3.0 s and 1 /e~2 beam diameters of 0.98 and 1.96 cm were employed. Damage lesion determinations were performed at 1- and 24 h post exposure. The Bliss probit analysis was employed to establish the ED_(50) damage thresholds. Histopathological studies of skin damage were performed at 48 h after irradiation to reveal the damage characteristics. The skin damage thresholds at 1 h post exposure, given in peak radiant exposure, were 35.5, 36.1, and 37.1 J/cm~2 at exposure durations of 0.4, 1.0, and 3.0 s with the spot diameter of 0.98 cm, and 28.6 J/cm~2 at exposure duration of 3.0 s with the spot diameter of 1.96 cm. At 24 h post exposure, the ED_(50)s increased slightly. Histologically, the thermal damage characteristics at the near-threshold level included gathering of the nuclear chromatin and cell vacuolation in the epidermis and deposition of blood cells in the capillary vessels. However, at the apparently above-threshold level, the damage characteristics included obvious stretching of the nuclear chromatin in the epidermis, closing of the capillary lumen, structural change of collagen fibers, and coagulative necrosis of the hair follicle cells. The damage induced by this laser could go deep into the fatty tissue. The obtained results may contribute to the knowledge base for the damage mechanisms and expand the database for the refinement of laser safety standards in the wavelength range of 1300 to 1400 nm.
机译：在1300至1400 nm光谱范围内工作的生物医学应用中，近红外激光的使用越来越多。为了证实和扩大现有皮肤在该波长区域内暴露于激光的安全性数据，在贵州小型猪中确定了1319 nm激光辐射的体内ED_（50）损伤阈值。曝光时间为0.4、1.0和3.0 s，1 / e〜2光束直径为0.98和1.96 cm。在暴露后1小时和24小时进行损伤损伤的测定。采用布利斯概率分析来建立ED_（50）损伤阈值。在照射后48小时进行皮肤损伤的组织病理学研究以揭示损伤特征。暴露后1 h的皮肤损伤阈值以峰值辐射暴露给出，在0.4、1.0和3.0 s的暴露时间，光斑直径为0.98 cm和28.6 J的条件下分别为35.5、36.1和37.1 J / cm〜2曝光持续时间为3.0 s / cm〜2，光斑直径为1.96 cm。暴露后24小时，ED_（50）s略有增加。组织学上，在接近阈值水平的热损伤特征包括核染色质的聚集和表皮中的细胞空泡化以及毛细血管中的血细胞沉积。然而，在明显高于阈值的水平，损伤特征包括表皮中核染色质的明显拉伸，毛细血管腔的闭合，胶原纤维的结构变化以及毛囊细胞的凝集性坏死。该激光引起的损伤可能深入脂肪组织。所获得的结果可能有助于损伤机理的知识库，并扩展数据库以完善1300至1400 nm波长范围内的激光安全标准。

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