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首页> 外文期刊>Journal of biomedical optics >In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances
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In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances

机译：通过光学相干弹性成像在不同交联辐照度下体内评估角膜的生物力学性能

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摘要

Corneal collagen cross-linking (CXL) strengthens the biomechanical properties of damaged corneas. Quantifying the changes of stiffness due to different CXL protocols is difficult, especially in vivo. A noninvasive elastic wave-based optical coherence elastography system was developed to construct in vivo corneal elasticity maps by excitation of air puff. Biomechanical differences were compared for rabbit corneas given three different CXL protocols while keeping the total energy delivered constant. The Young's modulus was weaker in corneas treated with higher irradiance levels over shorter durations, and a slight increase of Young's modulus was present in all groups one week after the recovery process. Due to the noninvasive nature and minimal force to generate corneal elastic waves, this technique has the potential for early detection and treatment of corneal diseases in clinic.
机译：角膜胶原蛋白交联（CXL）增强了受损角膜的生物力学性能。量化由于不同的CXL方案导致的硬度变化非常困难，尤其是在体内。开发了一种非侵入性的基于弹性波的光学相干弹性成像系统，以通过吹气来构建体内角膜弹性图。在保持总能量传递不变的情况下，比较了三种不同CXL协议对兔角膜的生物力学差异。在较高的辐照度水平下，在较短的持续时间内，角膜的杨氏模量较弱，恢复过程一周后所有组的杨氏模量均略有增加。由于无创性和产生角膜弹性波的力最小，该技术具有在临床中早期检测和治疗角膜疾病的潜力。

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