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首页> 外文期刊>Journal of biomedical optics >Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins
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Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins

机译：微型光谱成像设备，用于乳腺癌边缘的形态学景观的广域定量功能成像

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摘要

We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [µ~'_s(λ) and µ_a(λ)] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x, y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 x 2 cm~2 area in -9 min. The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibro-glandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.
机译：我们已经开发出一种便携式的乳腺切缘评估探针，该探针利用漫射光谱来量化在保乳手术期间乳腺肿瘤切缘的形态。此处介绍的方法利用了定制的16通道环形光电二极管成像阵列（以4×4网格排列），具有精确压力控制的光栅扫描成像平台以及在可见光中具有优化的八个波长组的压缩传感。光谱范围。基于可扩展的基于蒙特卡洛的逆模型用于为16个同时捕获的漫反射光谱中的每一个生成光学特性[µ _'_ s（λ）和µ_a（λ）]度量。通过对成像探头的x，y光栅进行增量扫描来实现亚像素采样（0.75 mm），从而在-9分钟内提供2 x 2 cm〜2区域内乳房边缘的详细光学参数图。使用光学替代物测定脂肪与纤维腺含量的比例来表征肿瘤边缘的形态，这已证明可用于描述乳腺的组织亚型。

著录项

  • 来源
    《Journal of biomedical optics》 |2017年第2期|026007.1-026007.16|共16页
  • 作者

    Brandon S. Nichols; Antonio Llopis; Gregory M. Palmer; Samuel S. McCachren lll; Ozlem Senlik; David Miller; Martin A. Brooke; Nan M. Jokerst; Joseph Geradts; Rachel Greenup; Nimmi Ramanujam;

  • 作者单位

    Duke University, Pratt School of Engineering, Department of Biomedical Engineering, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States;

    Duke University Medical Center, Department of Radiation Oncology, Medicine Circle, Durħam, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Biomedical Engineering, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Electrical Engineering, Durham, North Carolina, United States;

    Duke University Medical Center, Department of Pathology, Durham, North Carolina, United States;

    Duke University Medical Center, Department of Surgery, Durham, North Carolina, United States;

    Duke University, Pratt School of Engineering, Department of Biomedical Engineering, Durham, North Carolina, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    optics; photonics; diffuse optical spectroscopy; medical instrumentation; clinical applications; light propagation in tissue;

    机译：光学;光子学漫射光谱医疗仪器;临床应用;光在组织中的传播;

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