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首页> 外文期刊>Journal of biomedical optics >Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study
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Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study

机译：宏观单线态氧模型用于Photofrin介导的光动力疗法剂量学的体内研究

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摘要

Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates (φ). A macroscopic model was adopted to evaluate using calculated reacted singlet oxygen concentration ([~1O_2]_(rx)) to predict Photofrin-PDT outcome in mice bearing radiation-induced fibrosarcoma tumors, as singlet oxygen is the primary cytotoxic species responsible for cell death in type II PDT. Using a combination of fluences (50,135, 200, and 250 J/cm~2) and φ(50, 75, and 150 mW/cm~2), tumor regrowth rate, k, was determined for each condition. A tumor cure index, CI = 1 - k/k~(control), was calculated based on the k between PDT-treated groups and that of the control, k~(control). The measured Photofrin concentration and light dose for each mouse were used to calculate PDT dose and [~1O_2]_(rx), while mean optical properties (μa = 0.9 cm~(-1),μ's = 8.4 cm~(-1)) were used to calculate φ for all mice. CI was correlated to the fluence, PDT dose, and [~1O_2]_(rx) with R~2 = 0.35, 0.79, and 0.93, respectively. These results suggest that [~1O_2]_(rx) serves as a better dosimetric quantity for predicting PDT outcome.
机译：尽管光动力疗法（PDT）是一种已确立的癌症治疗方法，但是当前的剂量学量（例如光通量和PDT剂量）并未考虑不同通量率（φ）下PDT耗氧量的差异。采用宏观模型进行评估，使用计算出的反应单线态氧浓度（[〜1O_2] _（rx））预测患有放射性纤维肉瘤肿瘤的小鼠的Photofrin-PDT结果，因为单线态氧是导致细胞死亡的主要细胞毒性物质在II型PDT中。使用注量（50、135、200和250 J / cm〜2）和φ（50、75和150 mW / cm〜2）的组合，确定每种情况下的肿瘤再生率k。基于PDT治疗组和对照组k〜（对照）之间的k，计算出肿瘤治愈指数CI = 1-k / k〜（对照）。测量的每只小鼠的光敏蛋白浓度和光剂量用于计算PDT剂量和[〜1O_2] _（rx），而平均光学特性（μa= 0.9 cm〜（-1），μ's = 8.4 cm〜（-1） ）用于计算所有小鼠的φ。 CI与注量，PDT剂量和[〜1O_2] _（rx）相关，R〜2分别为0.35、0.79和0.93。这些结果表明，[〜1O_2] _（rx）可作为预测PDT结果的较好剂量。

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  • 来源
    《Journal of biomedical optics》 |2016年第8期|088002.1-088002.9|共9页
  • 作者

    Haixia Qiu; Michele M. Kim; Rozhin Penjweini; Timothy C. Zhu;

  • 作者单位

    Chinese PLA General Hospital, Department of Laser Medicine, No. 28 Fuxing Road, Haidian District, Beijing 100853, China,University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States;

    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States,University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States;

    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States;

    University of Pennsylvania, School of Medicine, Department of Radiation Oncology, 3400 Civic Center Boulevard TRC 4W, Philadelphia, Pennsylvania 19104, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    photodynamic therapy; singlet oxygen; Photofrin; photodynamic therapy explicit dosimetry; macroscopic model;

    机译：光动力疗法;单线态氧感光素;光动力疗法显式剂量法;宏观模型;

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