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Near-infrared imaging of the sinuses: preliminary evaluation of a new technology for diagnosing maxillary sinusitis

机译：鼻窦的近红外成像：诊断上颌窦炎的新技术的初步评估

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摘要

Diagnosing sinusitis remains a challenge for primary care physicians. There is a need for a simple, office-based technique to aid in the diagnosis of sinusitis without the cost and radiation risk of conventional radiologic imaging. We designed a low-cost near-infrared (NIR) device to transilluminate the maxillary sinuses. The use of NIR light allows for greater interrogation of deep-tissue structures as compared to visible light. NIR imaging of 21 patients was performed and compared with computed tomography (CT) scans. Individual maxillary sinuses were scored on a scale from 0 to 2 based on their degree of aeration present on CT and similarly based on the NIR signal penetration into the maxilla on NIR images. Our results showed that air-filled and fluid/tissue-filled spaces can be reasonably distinguished by their differing NIR signal penetration patterns, with average NIR imaging scores for fluid-filled maxillary sinuses (0.93±0.78, n=29) significantly lower than those for normal maxillary sinuses (1.62±0.57, n=13) (p=0.003). NIR imaging of the sinuses is a simple, safe, and cost-effective modality that can potentially aid in the diagnosis of sinusitis. Long-term, significant device refinement and large clinical trials will be needed to determine the diagnostic accuracy of this technique.
机译：对鼻窦炎的诊断仍然是基层医疗医生的挑战。需要一种简单的，基于办公室的技术来辅助鼻窦炎的诊断，而又不具有常规放射成像的成本和放射风险。我们设计了一种低成本的近红外（NIR）设备来透射上颌窦。与可见光相比，近红外光的使用允许对深层组织结构进行更大程度的询问。对21例患者进行了NIR成像，并与计算机断层扫描（CT）扫描进行了比较。根据上颌窦在CT上的通气程度，以及类似地基于NIR信号在NIR图像上穿透上颌的评分，评分范围为0到2。我们的结果表明，充气的和液体/组织填充的空间可以通过其不同的NIR信号穿透模式来合理地区分，液体上颌窦的平均NIR成像得分（0.93±0.78，n = 29）显着低于那些对于正常的上颌窦（1.62±0.57，n = 13）（p = 0.003）。鼻窦的NIR成像是一种简单，安全且具有成本效益的方式，可以潜在地帮助诊断鼻窦炎。为了确定该技术的诊断准确性，需要进行长期的，重大的设备改进和大型临床试验。

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  • 来源
    《Journal of biomedical optics》 |2010年第3期|p.036011.1-036011.5|共5页
  • 作者

    Usama Mahmood; Albert Cerussi; Reza Dehdari; Quoc Nguyen; Timothy Kelley; Bruce Tromberg; Brian Wong;

  • 作者单位

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

    University of California at Irvine Department of Biomedical Engineering and Department of Otolaryngology-Head and Neck Surgery Beckman Laser Institute 1002 Health Sciences Road Irvine, California 92612;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    infrared imaging; sinusitis; otolaryngology;

    机译：红外成像鼻窦炎;耳鼻喉科;

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