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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Calcium-binding protein S100P and cancer: mechanisms and clinical relevance
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Calcium-binding protein S100P and cancer: mechanisms and clinical relevance

机译：钙结合蛋白S100P与癌症的关系：机制和临床意义

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摘要

S100P is a 95-amino-acid protein and a member of the S100 family. It was first purified from placenta. The promoter area of S100P has binding sites for SMAD, STAT/CREB and SP/KLF, key regulatory elements participating in transcriptional activation of the S100P gene. Increased levels of S100P have been observed in multiple tumor cell lines and breast, pancreas, lung and ovary carcinomas. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
机译：S100P是一种95个氨基酸的蛋白质，是S100家族的成员。首先从胎盘中纯化。 S100P的启动子区域具有SMAD，STAT / CREB和SP / KLF的结合位点，SMAD，STAT / CREB和SP / KLF是参与S100P基因转录激活的关键调控元件。在多种肿瘤细胞系和乳腺癌，胰腺癌，肺癌和卵巢癌中均观察到S100P水平升高。已证明S100P通过结合Ca2 +离子，晚期糖基化终产物的受体，细胞骨架蛋白ezrin，钙调蛋白结合蛋白/ Siah-1相互作用蛋白和组织蛋白酶D介导肿瘤的生长，转移和侵袭。可能作为不同癌症的诊断标志物，预后/预测指标和治疗目标。

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    Hongfei Jiang; Hang Hu; Xiaomei Tong; Qiuhong Jiang; Haiyan Zhu; Songying Zhang;

  • 作者单位

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, #3 East Qing Chun Road, Hangzhou, 310016, Zhejiang, China;

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, #3 East Qing Chun Road, Hangzhou, 310016, Zhejiang, China;

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, #3 East Qing Chun Road, Hangzhou, 310016, Zhejiang, China;

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, #3 East Qing Chun Road, Hangzhou, 310016, Zhejiang, China;

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, College of Medic;

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  • 关键词

    S100P; Carcinogenesis; Tumor diagnosis;

    机译：S100P;致癌作用;肿瘤诊断;

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