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PAX3/7–FOXO1 fusion status in older rhabdomyosarcoma patient population by fluorescent in situ hybridization

机译:荧光原位杂交技术检测老年横纹肌肉瘤患者PAX3 / 7–FOXO1融合状态

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摘要

In pediatric alveolar rhabdomyosarcoma, the PAX3–FOXO1 and PAX7–FOXO1 gene fusions are prognostic indicators, while little is known concerning this disease in older patients. To determine whether PAX3/7–FOXO1 fusion gene status correlates with outcome in adolescent, young adult, and adult rhabdomyosarcoma patients, the histological, immunohistochemical, and clinical characteristics of 105 patients followed at The University of Texas MD Anderson Cancer Center from 1957 to 2001 were evaluated.
机译:在小儿肺泡横纹肌肉瘤中,PAX3–FOXO1和PAX7–FOXO1基因融合是预后指标,而对于老年患者这种疾病知之甚少。为了确定PAX3 / 7–FOXO1融合基因的状态是否与青少年,年轻成人和成人横纹肌肉瘤患者的预后相关,于1957年至2001年在德克萨斯大学MD安德森癌症中心追踪了105例患者的组织学,免疫组化和临床特征被评估。

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