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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer
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VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer

机译：VEGF基因的选择性剪接：癌症中的促血管生成和抗血管生成同种型

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摘要

Tumor growth and progression depend on angiogenesis, a process of new blood vessels formation from a preexisting vascular endothelium. Tumors promote angiogenesis by secreting or activating angiogenic factors that stimulate endothelial proliferation and migration and capillary morphogenesis. The newly formed blood vessels provide nutrients and oxygen to the tumor, increasing its growth. Thus, angiogenesis plays a key role in cancer progression and development of metastases. An important growth factor that promotes angiogenesis and participates in a variety of physiological and pathological processes is the vascular endothelial growth factor (VEGF-A or VEGF). Overexpression of VEGF results in increased angiogenesis in normal and pathological conditions. The existence of an alternative site of splicing at the 3′ untranslated region of the mRNA results in the expression of isoforms with a C-terminal region which are downregulated in tumors and may have differential inhibitory effects. This suggests that control of splicing can be an important regulatory mechanism of angiogenesis in cancer.
机译：肿瘤的生长和进展取决于血管生成，血管生成是从先前存在的血管内皮形成新血管的过程。肿瘤通过分泌或激活刺激内皮细胞增殖和迁移以及毛细血管形态发生的血管生成因子来促进血管生成。新形成的血管为肿瘤提供营养和氧气，从而促进了肿瘤的生长。因此，血管生成在癌症进展和转移的发展中起关键作用。促进血管生成并参与各种生理和病理过程的重要生长因子是血管内皮生长因子（VEGF-A或VEGF）。 VEGF的过度表达导致正常和病理条件下血管生成的增加。在mRNA的3'非翻译区存在剪接的替代位点，导致具有C末端区域的同工型的表达在肿瘤中被下调并且可能具有不同的抑制作用。这表明剪接的控制可能是癌症中血管生成的重要调节机制。

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  • 来源
    《Journal of Cancer Research and Clinical Oncology》 |2012年第3期|p.363-370|共8页
  • 作者

    P. M. Biselli-Chicote; A. R. C. P. Oliveira; E. C. Pavarino; E. M. Goloni-Bertollo;

  • 作者单位

    Genetics and Molecular Biology Research Unit - UPGEM, Medical School of Sao Jose do Rio Preto - FAMERP, Av. Brigadeiro Faria Lima, 5416, Bloco U6, Sao Jose do Rio Preto, SP, 15090-000, Brazil;

    Genetics and Molecular Biology Research Unit - UPGEM, Medical School of Sao Jose do Rio Preto - FAMERP, Av. Brigadeiro Faria Lima, 5416, Bloco U6, Sao Jose do Rio Preto, SP, 15090-000, Brazil;

    Genetics and Molecular Biology Research Unit - UPGEM, Medical School of Sao Jose do Rio Preto - FAMERP, Av. Brigadeiro Faria Lima, 5416, Bloco U6, Sao Jose do Rio Preto, SP, 15090-000, Brazil;

    Genetics and Molecular Biology Research Unit - UPGEM, Medical School of Sao Jose do Rio Preto - FAMERP, Av. Brigadeiro Faria Lima, 5416, Bloco U6, Sao Jose do Rio Preto, SP, 15090-000, Brazil;

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  • 正文语种 eng
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  • 关键词

    Cancer; Angiogenesis; VEGF gene; Alternative splicing;

    机译：癌症;血管生成;VEGF基因;选择性剪接;

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