首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines
【24h】

RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines

机译:RUNX3参与由5-氮杂-CdR和TSA联合诱导的白血病细胞株诱导的caspase-3依赖性凋亡

获取原文
获取原文并翻译 | 示例
           

摘要

Epigenetic therapy has had a significant impact on the management of haematologic malignancies. The aim of this study was to assess whether 5-aza-CdR and TSA inhibit the growth of leukaemia cells and induce caspase-3-dependent apoptosis by upregulating RUNX3 expression.
机译:表观遗传学治疗对血液系统恶性肿瘤的治疗有重要影响。这项研究的目的是评估5-氮杂CdR和TSA是否通过上调RUNX3表达来抑制白血病细胞的生长并诱导caspase-3依赖性凋亡。

著录项

  • 来源
    《Journal of Cancer Research and Clinical Oncology》 |2012年第3期|p.439-449|共11页
  • 作者单位

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

    Department of Hematology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Runt-related transcription factor 3 (RUNX3); Chronic myeloid leukaemia (CML); 5-aza-2-deoxycytidine (5-aza-CdR); TSA (trichostatin A);

    机译:矮子相关转录因子3(RUNX3);慢性髓细胞性白血病(CML);5-氮杂-2-脱氧胞苷(5-氮杂-CdR);TSA(曲古抑菌素A);

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号