首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event
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High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event

机译:高KIT和PDGFRA与胃肠道胰腺神经内分泌肿瘤患者的生存期缩短有关,但突变是罕见的事件

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摘要

(1) To test whether in genomewide expression profiling differentially expressed genes were also distinct on the protein level including KIT and PDGFRA (2) to correlate the expression with clinicopathological parameters (3) to identify activating mutations that might be eligible for tyrosine kinase inhibitor therapy by mutational analysis of tumors with high expression.
机译:(1)测试在全基因组表达谱中差异表达的基因在蛋白水平(包括KIT和PDGFRA)上是否也不同(2)使表达与临床病理参数相关(3)以鉴定可能适合酪氨酸激酶抑制剂治疗的激活突变通过对高表达肿瘤的突变分析。

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