Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers

Ana Custodio; Antonio J. López-Farré; José J. Zamorano-León; Petra J. Mateos-Cáceres; Carlos Macaya; Trinidad Caldés; Miguel de la Hoya; Elena Olivera; Javier Puente; Eduardo Díaz-Rubio; Pedro Pérez-Segura

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Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers

机译：BRCA1突变携带者中与血栓形成相关的血浆蛋白表达的变化

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Although BRCA1 gene mutations have been associated with breast cancer, BRCA1 mutations have been also involved in other functions. Thrombosis and coagulation are novel mechanisms recently associated with cancer. The aims of the present study were (a) to evaluate, using proteomics, if BRCA1 mutation carriers have a different plasma proteins expression related to thrombosis and coagulation profile than non-mutant BRCA1 women and (b) to analyze if the expression of these proteins may be different among BRCA1 mutation carriers with and without breast cancer.

机译：尽管BRCA1基因突变与乳腺癌有关，但BRCA1突变也与其他功能有关。血栓形成和凝血是最近与癌症相关的新机制。本研究的目的是（a）使用蛋白质组学评估BRCA1突变携带者是否与非突变BRCA1妇女具有与血栓形成和凝血特性相关的血浆蛋白表达，以及（b）分析这些蛋白的表达在有或没有乳腺癌的BRCA1突变携带者之间可能有所不同。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2012年第5期|p.867-875|共9页
作者
Ana Custodio; Antonio J. López-Farré; José J. Zamorano-León; Petra J. Mateos-Cáceres; Carlos Macaya; Trinidad Caldés; Miguel de la Hoya; Elena Olivera; Javier Puente; Eduardo Díaz-Rubio; Pedro Pérez-Segura;
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作者单位

Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), C/Profesor Martín Lagos, s, 28040, Madrid, Spain;

Cardiovascular Research Unit of Cardiology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), C/Profesor Martín Lagos, s, 28040, Madrid, Spain;

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正文语种 eng
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关键词
Breast cancer; BRCA1 gene; Proteomics; Thrombosis;

机译：乳腺癌;BRCA1基因;蛋白质组学;血栓形成;

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1. Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers. [J] . Ana Custodio, Antonio J López-Farré, José J Zamorano-León, Journal of Cancer Research and Clinical Oncology . 2012,第5期

机译：BRCA1突变携带者中与血栓形成相关的血浆蛋白表达的变化。
2. The expression of BRCA1, P53, KAI1, and Nm23 in ovaries of BRCA1 mutation carriers after prophylactic adnexectomy [J] . MarkowskaJ., BarJ., Ma?dryR., Archives of gynecology and obstetrics. . 2013,第4期

机译：预防性附件切除术后BRCA1突变携带者卵巢中BRCA1，P53，KAI1和Nm23的表达
3. Prevalence of BRCA1 mutations and responses to neoadjuvant chemotherapy among BRCA1 carriers and non-carriers with triple-negative breast cancer [J] . Wang C., Zhang J., Wang Y., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第3期

机译：三阴性乳腺癌BRCA1携带者和非携带者中BRCA1突变的发生率和对新辅助化疗的反应
4. N-terminal mutations of the human estrogen receptor gene alter expression and function of its protein product [C] . Klaus Graumann, Wenke Feng, Alois Jungbauer, Asia-Pacific biochemical engineering conference;APBIOCHEC'97 . 1997

机译：人类雌激素受体基因的N端突变会改变其蛋白质产物的表达和功能
5. BRCA1 and BRCA2 Mutation Carrier Perspectives on Direct-to-Consumer Genetic Testing for BRCA Mutations [D] . Mitchell, Caitlyn E. 2019

机译：BRCA1和BRCA2突变载体对BRCA突变的直接消费遗传检测的视角
6. The expression of BRCA1 P53 KAI1 and Nm23 in ovaries of BRCA1 mutation carriers after prophylactic adnexectomy [O] . J. Markowska, J. Bar, R. Mądry, -1

机译：预防性附件切除术后BRCA1突变携带者卵巢中BRCA1P53KAI1和Nm23的表达
7. Prevalence of BRCA1 Mutations and Responses to Neoadjuvant Chemotherapy among BRCA1 Carriers and Non-carriers with Triple-negative Breast Cancer [O] . B. Lin, Y. Xie 2014

机译：BRCa1携带者和三阴性乳腺癌非携带者BRCa1突变和新辅助化疗反应的患病率

Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers

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