Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide

H. Sayer; U. Will; K. Schilling; T. Vogt; K. Wollina; K. Höffken

首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide

【24h】

Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide

机译：串联自体干细胞移植后肝小静脉完全闭塞的肝静脉闭塞性疾病-大剂量甲基强的松龙和去纤蛋白的成功治疗

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Veno-occlusive disease (VOD) is a life-threatening complication following allogeneic or autologous stem cell transplantation. We report on a patient with a high grade B-cell lymphoma who presented 28 days after the second autologous stem cell transplantation with weight gain, ascites, hyperbilirubinemia, and liver venules occlusion as demonstrated by sonography. Starting with high-dose methylprednisolone treatment followed by defibrotide maintenance therapy the patient showed dramatic complete response of VOD, resulting in a normal sonography of the liver and normalization of laboratory values. The response of the occlusion of nearly all liver venules underlines the value of anti-inflammatory treatment combined with new thrombolytic medication such as defibrotide for the treatment of severe VOD.

机译：静脉闭塞性疾病（VOD）是同种异体或自体干细胞移植后威胁生命的并发症。我们报道了一位患有高级别B细胞淋巴瘤的患者，该患者在第二次自体干细胞移植后28天出现了体重增加，腹水，高胆红素血症和肝小静脉闭塞，如超声检查所示。从大剂量甲基强的松龙治疗开始，接着进行去纤蛋白维持治疗，患者表现出明显的VOD完全反应，从而使肝脏超声检查正常，实验室值正常。几乎所有肝小静脉闭塞的反应都强调了抗炎治疗与新的溶栓药物（如去纤肽）联合用于治疗严重VOD的价值。

著录项

来源
《Journal of Cancer Research and Clinical Oncology》 |2002年第3期|148-152|共5页
作者
H. Sayer; U. Will; K. Schilling; T. Vogt; K. Wollina; K. Höffken;
展开▼
作者单位

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

Klinik und Poliklinik für Innere Medizin II (Hämatologie Onkologie Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena Erlanger Allee 101 07740 Jena Germany;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
Allogeneic and autologous stem cell transplantation; Veno-occlusive disease; Sonography; High-dose methylprednisolone; Defibrotide;

机译：同种异体和自体干细胞移植;静脉阻塞性疾病;超声检查大剂量甲基泼尼松龙;去纤蛋白;

相似文献

外文文献
中文文献
专利

1. Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation-- successful treatment with high-dose methylprednisolone and defibrotide. [J] . Sayer HG, Will U, Schilling K, Journal of Cancer Research and Clinical Oncology . 2002,第3期

机译：串联自体干细胞移植后肝静脉闭塞性肝静脉闭塞性疾病（VOD）-用大剂量甲基强的松龙和去纤蛋白成功治疗。
2. DEFIBROTIDE TREATMENT OF NEUROBLASTOMA PATIENTS DEVELOPING HEPATIC VENO-OCCLUSIVE DISEASE/SINUSOIDAL OBSTRUCTION SYNDROME (VOD/SOS) POST-HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT): FINAL DATA FROM AN EXPANDED-ACCESS PROGRAM (T-IND) [J] . Grupp Stephan A., Marachelian Araz, Jodele Sonata, Pediatric blood & cancer . 2018,第Suppla1期

机译：神经母细胞瘤患者患肝静脉闭塞性疾病/正弦梗阻综合征（VOD / SOS）后造血干细胞移植（HSCT）的抗生素治疗：来自扩展程序（T-IND）的最终数据
3. DEFIBROTIDE TREATMENT OF NEUROBLASTOMA PATIENTS DEVELOPING HEPATIC VENO-OCCLUSIVE DISEASE/SINUSOIDAL OBSTRUCTION SYNDROME (VOD/SOS) POST-HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT): FINAL DATA FROM AN EXPANDED-ACCESS PROGRAM (T-IND) [J] . Grupp Stephan A., Marachelian Araz, Jodele Sonata, Pediatric blood & cancer . 2018,第Suppla1期

机译：神经母细胞瘤患者患肝静脉闭塞性疾病/正弦梗阻综合征（VOD / SOS）后造血干细胞移植（HSCT）的抗生素治疗：来自扩展程序（T-IND）的最终数据
4. HIGH-DOSE MELPHALAN CHEMOTHERAPY WITH AUTOLOGOUS STEM CELL TRANSPLANTATION IN 65 PATIENTS WITH AL AMYLOIDOSIS: ORGAN PROGRESSION CAN BE DELAYED IN PATIENTS REACHING COMPLETE REMISSION [C] . SO Schonland, J.B Dengler, M Hundemer, International Symposium on Amyloidosis . 2008

机译：在65例Al淀粉样蛋白患者中，具有自体蛋白化疗的高剂量蛋白化疗：器官进展可以延迟达到完全缓解的患者
5. Transplantation of genetically modified hepatocytes containing a copper-transporting ATPase, direct hepatic delivery, and the potential for the treatment of Wilson's disease. [D] . Sanchez, Rigoberto A. 2005

机译：含有铜转运ATPase的转基因肝细胞的移植，直接肝传递以及治疗威尔逊氏病的潜力。
6. High-Dose Methylprednisolone for Veno-Occlusive Disease of the Liver in Pediatric Hematopoietic Stem Cell Transplantation Recipients [O] . Kasiani C. Myers, Julia Lawrence, Rebecca A. Marsh, -1

机译：高剂量甲基己酮用于小儿造血干细胞移植受体的肝脏静脉闭塞病
7. Impact on Outcomes of Baseline Bilirubin in Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Stem Cell Transplant (HSCT) Receiving Defibrotide Treatment: A Post-Hoc Analysis [O] . Stephan A. Grupp, Angela R. Smith, Brandon M. Triplett, 2017

机译：造血干细胞移植（HSCT）接受除颤治疗后肝静脉闭塞疾病/正弦梗阻综合征（VOD / SOS）患者基线胆红素患者的影响：HOC分析后分析

Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide

摘要

著录项

相似文献

相关主题

期刊订阅