• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Chemical Biology >Synthetic molecules: helping to unravel plant signal transduction
【24h】

Synthetic molecules: helping to unravel plant signal transduction

机译：合成分子：帮助阐明植物信号转导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The application of small molecules has played a crucial role in identifying novel components involved in plant signalling. Compared to classic genetic approaches, small molecule screens offer notable advantages in dissecting plant biological processes, such as technical simplicity, low start-up costs, and most importantly, bypassing the problems of lethality and redundancy. To identify small molecules that target a biological process or protein of interest, robust and well-reasoned high-throughput screening approaches are essential. In this review, we present a series of principles and valuable approaches in small molecule screening in the plant model system Arabidopsis thaliana. We also provide an overview of small molecules that led to breakthroughs in uncovering phytohormone signalling pathways, endomembrane signalling cascades, novel growth regulators, and plant defence mechanisms. Meanwhile, the strategies to deciphering the mechanisms of these small molecules on Arabidopsis are highlighted. Moreover, the opportunities and challenges of small molecule applications in translational biology are discussed.
机译：小分子的应用在确定植物信号传导中涉及的新成分方面发挥了关键作用。与传统的遗传方法相比，小分子筛查在解剖植物生物学过程中具有显着的优势，例如技术简便，启动成本低，最重要的是，绕过了致死性和冗余性问题。为了鉴定靶向目标生物学过程或蛋白质的小分子，鲁棒且合理的高通量筛选方法必不可少。在这篇综述中，我们介绍了植物模型系统拟南芥中小分子筛选的一系列原理和有价值的方法。我们还概述了导致发现植物激素信号传导途径，内膜信号传导级联，新型生长调节剂和植物防御机制方面取得突破的小分子。同时，突出了解释这些小分子在拟南芥上的机制的策略。此外，讨论了小分子在转化生物学中的应用所面临的机遇和挑战。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号