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首页> 外文期刊>Journal of Clinical and Experimental Neuropsychology >Effect of age and glucoregulation on cognitive performance
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Effect of age and glucoregulation on cognitive performance

机译：年龄和糖调节对认知能力的影响

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Type 2 diabetes has been associated with a number of physiological consequences including neuropathy, retinopathy, and incidence of vascular disease. Less is known about the effect on cognition of prediabetes, a period when glucose regulation is abnormal. It is not clear which aspect of impaired glucoregulation is most predictive of cognitive deterioration. In the present experiment, we measured cognitive function in 93 healthy male and female nondiabetic older participants who ranged in age from 55 to 88 years. Various biological measures were obtained including a glucose tolerance test during which glucose and insulin were measured. Participants were evaluated twice, once after drinking a saccharin solution and on another occasion after drinking a glucose solution (50 g). The analysis of the correlations between the biological measures and the results of the cognitive tasks revealed that evoked glucose measures such as peak glucose and glucose at 1 hour were most often correlated with cognitive performance. We observed that progressively worse glucose regulation predicted poorer performance on measures of working memory and executive function—that is, on the Arithmetic, Digit Span Backward, Letter-Number Sequencing, Spatial Span Forward, Spatial Span Backward (trend), and Modified Brown-Peterson tasks. Although, there was no significant facilitative effect of glucose on cognitive performance, it reduced the association between glucose regulation and cognition, apparently by slightly improving performance. These results suggest that cognitive functions may be impaired before glucoregulatory impairment reaches levels consistent with a type 2 diabetes diagnosis.
机译：2型糖尿病与许多生理后果有关，包括神经病变，视网膜病变和血管疾病的发生。关于葡萄糖调节异常的糖尿病前期认知的影响知之甚少。目前尚不清楚糖调节异常的哪个方面最能预测认知能力的下降。在本实验中，我们测量了93名年龄在55至88岁之间的健康的男性和女性非糖尿病老年参与者的认知功能。获得了各种生物措施，包括葡萄糖耐量测试，在此期间测量了葡萄糖和胰岛素。参与者进行了两次评估，一次是在饮用糖精溶液后，另一次是在饮用葡萄糖溶液（50 g）后。对生物学指标与认知任务结果之间的相关性进行分析后发现，诱发的血糖指标（例如峰值葡萄糖和1小时时的血糖）最常与认知能力相关。我们观察到，葡萄糖调节的逐步恶化预示着在工作记忆和执行功能方面的表现较差，即在算术，数字范围后退，字母数字排序，空间范围前进，空间范围后退（趋势）和改良布朗-彼得森的任务。尽管葡萄糖对认知能力没有明显的促进作用，但显然可以稍微改善其表现，从而降低了葡萄糖调节与认知之间的联系。这些结果表明，在糖调节异常达到与2型糖尿病诊断一致的水平之前，认知功能可能已经受损。

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