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首页> 外文期刊>Journal of Clinical Pathology >Spindle cell melanocytic lesions-part I: an approach to compound naevoidal pattern lesions with spindle cell morphology and Spitzoid pattern lesions
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Spindle cell melanocytic lesions-part I: an approach to compound naevoidal pattern lesions with spindle cell morphology and Spitzoid pattern lesions

机译：梭形细胞黑素细胞性病变-第一部分：具有梭形细胞形态和Spitzoid形态性病变的复合性空洞型病变的方法

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摘要

Melanocytic lesions show great morphological diversity in their architecture and the cytomorphological appearance of their composite cells. Whereas functional melanocytes reveal a dendritic cytomorphology and territorial isolation, lesional naevomelanocytes and melanoma cells typically show epithelioid, spindled or mixed cytomorphologies and a range of architectural arrangements. Spindling is common to melanocytic lesions, and may be either a characteristic feature or a divergent appearance. The presence of spindle cells may mask the melanocytic nature of a lesion, and is often disconcerting, either because of its infrequent appearance in a particular lesion or its interpretation as a dedifferentiated phenotype. Spindle cell melanocytic lesions follow the full spectrum of potential biological outcomes, and difficulty may be experienced judging the nature of a lesion because of a lack of consistently reliable features to predict biological behaviour. Over time, recognition of numerous histomorphological features that may portend a more aggressive lesion have been identified. However, the translation of these features into a diagnostic entity requires a gestalt approach. Although most spindle cell melanocytic lesions can reliably be resolved with this standard approach, problem areas do exist and cause no end of grief to the surgical pathologist or dermatopathologist. In this review, the authors present their algorithmic approach to spindle cell melanocytic lesions and discuss each entity in turn, in order to (1) model a systematic approach to such lesions, and (2) provide familiarity with those melanocytic lesions that either typically or occasionally display a spindled cytomorphology.
机译：黑素细胞病灶在其结构和复合细胞的细胞形态学外观上表现出极大的形态多样性。功能性黑素细胞显示树突状细胞形态和领土隔离，而病灶性黑素细胞和黑素瘤细胞通常显示上皮样，纺锤状或混合细胞形态和一系列结构安排。纺锤体是黑素细胞病变的常见现象，可能是特征性特征或发散性外观。梭形细胞的存在可能掩盖病变的黑素细胞特性，并且常常令人不安，这是因为它在特定病变中很少出现或被解释为去分化的表型。纺锤体黑素细胞病变遵循所有潜在的生物学结果，由于缺乏一致可靠的特征来预测生物学行为，因此判断病变的性质可能会遇到困难。随着时间的流逝，已经识别出可能预示着更具侵袭性的病变的许多组织形态学特征。但是，将这些功能转换为诊断实体需要使用格式塔方法。尽管大多数梭形细胞黑素细胞病变都可以使用这种标准方法可靠地解决，但确实存在问题区域，并且不会给外科病理学家或皮肤病理学家带来痛苦。在这篇综述中，作者提出了他们对纺锤体黑素细胞病变的算法方法，并依次讨论了每个实体，以便（1）对此类病变进行系统的建模，以及（2）熟悉那些通常或偶有梭形细胞形态。

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  • 来源
    《Journal of Clinical Pathology》 |2010年第4期|P.296-321|共26页
  • 作者

    Shachar Sade; Ayman Al Habeeb; Danny Ghazarian;

  • 作者单位

    Department of Laboratory Medicine and Pathobiology University Health Network,Toronto, Canada;

    rnDepartment of Laboratory Medicine and Pathobiology University Health Network,Toronto, Canada;

    rnDepartment of Laboratory Medicine and Pathobiology University Health Network,Toronto, Canada Department of Pathology,Toronto General Hospital, 190 Elizabeth St, Toronto, Ontario M5G2C4, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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