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首页> 外文期刊>Journal of Cognitive Neuroscience >Inhibition of Pre-Supplementary Motor Area by Continuous Theta Burst Stimulation Leads to More Cautious Decision-making and More Efficient Sensory Evidence Integration
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Inhibition of Pre-Supplementary Motor Area by Continuous Theta Burst Stimulation Leads to More Cautious Decision-making and More Efficient Sensory Evidence Integration

机译：持续的Theta爆发刺激抑制前辅助运动区导致更谨慎的决策和更有效的感官证据整合

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摘要

Decisions are made based on the integration of available evidence. The noise in evidence accumulation leads to a particular speed-accuracy tradeoff in decision-making, which can be modulated and optimized by adaptive decision threshold setting. Given the effect of pre-SMA activity on striatal excitability, we hypothesized that the inhibition of pre-SMA would lead to higher decision thresholds and an increased accuracy bias. We used offline continuous theta burst stimulation to assess the effect of transient inhibition of the right pre-SMA on the decision processes in a free-response two-alternative forced-choice task within the drift diffusion model framework. Participants became more cautious and set higher decision thresholds following right pre-SMA inhibition compared with inhibition of the control site (vertex). Increased decision thresholds were accompanied by an accuracy bias with no effects on post-error choice behavior. Participants also exhibited higher drift rates as a result of pre-SMA inhibition compared with the vertex inhibition. These results, in line with the striatal theory of speed-accuracy tradeoff, provide evidence for the functional role of pre-SMA activity in decision threshold modulation. Our results also suggest that pre-SMA might be a part of the brain network associated with the sensory evidence integration.
机译：根据现有证据的整合做出决策。证据积累中的噪声会导致决策中的特定速度-准确性折衷，可以通过自适应决策阈值设置进行调制和优化。考虑到SMA前活性对纹状体兴奋性的影响，我们假设SMA前抑制会导致更高的决策阈值和更高的准确性偏倚。我们使用离线连续theta脉冲刺激来评估漂移扩散模型框架内自由响应的两种替代强迫选择任务中决策过程对正确的SMA前瞬态抑制的短暂影响。与对对照部位（顶点）的抑制相比，参与者在进行正确的SMA前抑制后变得更加谨慎，并设定了更高的决策阈值。决策阈值的提高伴随着准确性的偏差，而对误差后的选择行为没有影响。与顶点抑制相比，由于SMA前抑制，参与者还表现出更高的漂移率。这些结果符合速度精度折衷的纹状体理论，为SMA前活动在决策阈值调制中的功能作用提供了证据。我们的研究结果还表明，SMA前期可能是与感觉证据整合相关的大脑网络的一部分。

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