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首页> 外文期刊>Journal of Computational Neuroscience >Hallucinogen persisting perception disorder in neuronal networks with adaptation
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Hallucinogen persisting perception disorder in neuronal networks with adaptation

机译：致幻剂持续适应神经元网络中的感知障碍

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We study the spatiotemporal dynamics of neuronal networks with spike frequency adaptation. In particular, we compare the effects of adaptation being either a linear or nonlinear function of neural activity. We find that altering parameters controlling the strength of synaptic connections in the network can lead to spatially structured activity suggestive of symptoms of hallucinogen persisting perception disorder (HPPD). First, we study how both networks track spatially homogeneous flickering stimuli, and find input is encoded as continuous at lower flicker frequencies when the network's synapses exhibit more net excitation. Mainly, we study instabilities of stimulus-driven traveling pulse solutions, representative of visual trailing phenomena common to HPPD patients. Visual trails are reported as discrete afterimages in the wake of a moving input. Thus, we analyze several solutions arising in response to moving inputs in both networks: an ON state, stimulus-locked pulses, and traveling breathers. We find traveling breathers can arise in both networks when an input moves beyond a critical speed. These possible neural substrates of visual trails occur at slower speeds when the modulation of synaptic connectivity is increased.
机译：我们研究了具有尖峰频率适应性的神经元网络的时空动力学。特别是，我们比较了适应是神经活动的线性或非线性函数的影响。我们发现改变控制网络中的突触连接强度的参数可以导致暗示致幻剂持续性知觉障碍（HPPD）症状的空间结构化活动。首先，我们研究两个网络如何跟踪空间上均一的闪烁刺激，并发现当网络的突触表现出更多的净激励时，输入将在较低的闪烁频率下被编码为连续的。主要地，我们研究刺激驱动的行波脉冲解的不稳定性，代表了HPPD患者常见的视觉拖尾现象。视觉轨迹在移动输入后被报告为离散的残像。因此，我们分析了响应于两个网络中的移动输入而产生的几种解决方案：“ ON”状态，刺激锁定脉冲和行进呼吸。我们发现，当输入超出临界速度时，两个网络中都可能出现旅行呼吸。当突触连接性的调节增加时，这些视觉线索的可能神经底物以较慢的速度发生。

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