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首页> 外文期刊>Journal of Computational Neuroscience >Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study
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Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study

机译：大脑深部刺激和损伤期间局部细胞以及通过的纤维激活和沉默对丘脑保真度变化的相对贡献：计算模型研究

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Deep brain stimulation (DBS) and lesioning are two surgical techniques used in the treatment of advanced Parkinson's disease (PD) in patients whose symptoms are not well controlled by drugs, or who experience dyskinesias as a side effect of medications. Although these treatments have been widely practiced, the mechanisms behind DBS and lesioning are still not well understood. The subthalamic nucleus (STN) and globus pallidus pars interna (GPi) are two common targets for both DBS and lesioning. Previous studies have indicated that DBS not only affects local cells within the target, but also passing axons within neighboring regions. Using a computational model of the basal ganglia-thalamic network, we studied the relative contributions of activation and silencing of local cells (LCs) and fibers of passage (FOPs) to changes in the accuracy of information transmission through the thalamus (thalamic fidelity), which is correlated with the effectiveness of DBS. Activation of both LCs and FOPs during STN and GPi-DBS were beneficial to the outcome of stimulation. During STN and GPi lesioning, effects of silencing LCs and FOPs were different between the two types of lesioning. For STN lesioning, silencing GPi FOPs mainly contributed to its effectiveness, while silencing only STN LCs did not improve thalamic fidelity. In contrast, silencing both GPi LCs and GPe FOPs during GPi lesioning contributed to improvements in thalamic fidelity. Thus, two distinct mechanisms produced comparable improvements in thalamic function: driving the output of the basal ganglia to produce tonic inhibition and silencing the output of the basal ganglia to produce tonic disinhibition. These results show the importance of considering effects of activating or silencing fibers passing close to the nucleus when deciding upon a target location for DBS or lesioning.
机译：深部脑刺激（DBS）和病变是两种用于治疗晚期帕金森氏病（PD）的外科手术技术，这些患者的症状不能通过药物很好地控制，或者经历运动障碍作为药物的副作用。尽管已经广泛实践了这些治疗方法，但对DBS和损伤的机制仍不甚了解。丘脑下核（STN）和苍白球间（GPi）是DBS和病变的两个常见目标。先前的研究表明，DBS不仅影响靶标内的局部细胞，而且还会影响邻近区域内的轴突。使用基底神经节-丘脑网络的计算模型，我们研究了局部细胞（LCs）和通道纤维（FOPs）的激活和沉默对丘脑信息传递准确性变化的相关贡献（丘脑保真度），这与星展银行的有效性有关。 STN和GPi-DBS期间LC和FOP的激活均对刺激结果有益。在STN和GPi病变期间，两种类型的病变之间LC和FOP沉默效果不同。对于STN损伤，沉默GPi FOP对其有效性起主要作用，而仅沉默STN LC并不能改善丘脑保真度。相比之下，在GPi损伤期间使GPi LC和GPe FOP都沉默有助于改善丘脑保真度。因此，两种不同的机制在丘脑功能方面产生了可比的改善：驱动基底神经节的输出以产生强直抑制和沉默基底神经节的输出以产生强直抑制。这些结果表明，在决定DBS或病变的目标位置时，必须考虑激活或沉默接近核的纤维的影响。

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