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首页> 外文期刊>Journal of Computational Neuroscience >Phase precession through acceleration of local theta rhythm: a biophysical model for the interaction between place cells and local inhibitory neurons
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Phase precession through acceleration of local theta rhythm: a biophysical model for the interaction between place cells and local inhibitory neurons

机译：通过加速局部θ节律的相位进动：放置细胞和局部抑制性神经元之间相互作用的生物物理模型

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摘要

Phase precession is one of the most well known examples within the temporal coding hypothesis. Here we present a biophysical spiking model for phase precession in hippocampal CA1 which focuses on the interaction between place cells and local inhibitory interneurons. The model's functional block is composed of a place cell (PC) connected with a local inhibitory cell (IC) which is modulated by the population theta rhythm. Both cells receive excitatory inputs from the entorhinal cortex (EC). These inputs are both theta modulated and space modulated. The dynamics of the two neuron types are described by integrate-and-fire models with conductance synapses, and the EC inputs are described using non-homogeneous Poisson processes. Phase precession in our model is caused by increased drive to specific PC/IC pairs when the animal is in their place field. The excitation increases the IC's firing rate, and this modulates the PC's firing rate such that both cells precess relative to theta. Our model implies that phase coding in place cells may not be independent from rate coding. The absence of restrictive connectivity constraints in this model predicts the generation of phase precession in any network with similar architecture and subject to a clocking rhythm, independently of the involvement in spatial tasks.
机译：相位进动是时间编码假设中最著名的例子之一。在这里，我们介绍了海马CA1进动的生物物理峰值模型，该模型着重于位置细胞和局部抑制性中间神经元之间的相互作用。该模型的功能块由与局部抑制细胞（IC）连接的位置细胞（PC）组成，该局部抑制细胞由种群theta节奏调节。两种细胞都从内嗅皮层（EC）接收兴奋性输入。这些输入均经过θ调制和空间调制。两种神经元类型的动力学通过具有电导突触的积分和发射模型进行描述，而EC输入则使用非均匀的Poisson过程进行描述。我们的模型中的相位进动是由于当动物处于其放置区域时对特定PC / IC对的驱动增加而引起的。激励提高了IC的发射速率，从而调制了PC的发射速率，使得两个单元都相对于θ进动。我们的模型暗示位置单元中的相位编码可能不独立于速率编码。此模型中没有限制性的连通性约束，可以预测在具有类似架构且受制于时钟节奏的任何网络中相位进动的产生，而与空间任务的参与无关。

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