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首页> 外文期刊>Journal of Computational Neuroscience >The effects of DBS patterns on basal ganglia activity and thalamic relay
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The effects of DBS patterns on basal ganglia activity and thalamic relay

机译：DBS模式对基底神经节活动和丘脑中继的影响

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摘要

Thalamic neurons receive inputs from cortex and their responses are modulated by the basal ganglia (BG). This modulation is necessary to properly relay cortical inputs back to cortex and downstream to the brain stem when movements are planned. In Parkinson's disease (PD), the BG input to thalamus becomes pathological and relay of motor-related cortical inputs is compromised, thereby impairing movements. However, high frequency (HF) deep brain stimulation (DBS) may be used to restore relay reliability, thereby restoring movements in PD patients. Although therapeutic, HF stimulation consumes significant power forcing surgical battery replacements, and may cause adverse side effects. Here, we used a biophysical-based model of the BG-Thalamus motor loop in both healthy and PD conditions to assess whether low frequency stimulation can suppress pathological activity in PD and enable the thalamus to reliably relay movement-related cortical inputs. We administered periodic pulse train DBS waveforms to the sub-thalamic nucleus (STN) with frequencies ranging from 0-140 Hz, and computed statistics that quantified pathological bursting, oscillations, and synchronization in the BG as well as thalamic relay of cortical inputs. We found that none of the frequencies suppressed all pathological activity in BG, though the HF waveforms recovered thalamic reliability. Our rigorous study, however, led us to a novel DBS strategy involving low frequency multi-input phase-shifted DBS, which successfully suppressed pathological symptoms in all BG nuclei and enabled reliable thalamic relay. The neural restoration remained robust to changes in the model parameters characterizing early to late PD stages.
机译：丘脑神经元从皮质接受输入，其反应由基底神经节（BG）调节。当计划运动时，此调制对于正确地将皮质输入中继回皮质并向脑干的下游传递是必需的。在帕金森氏病（PD）中，丘脑的BG输入变得病理化，并且与运动相关的皮质输入的传递受到损害，从而损害了运动。但是，可以使用高频（HF）深部脑刺激（DBS）恢复中继的可靠性，从而恢复PD患者的运动。尽管是治疗性的，但HF刺激会消耗大量功率，从而迫使需要更换外科手术电池，并且可能会引起不利的副作用。在这里，我们在健康和PD条件下都使用了基于BG-丘脑运动回路的生物物理模型来评估低频刺激是否可以抑制PD的病理活动并使丘脑能够可靠地传递与运动相关的皮质输入。我们将周期性脉冲序列DBS波形以0-140 Hz的频率施加到丘脑下核（STN），并计算统计数据，以量化BG以及皮层输入的丘脑中继中的病理性猝发，振荡和同步。我们发现，尽管HF波形恢复了丘脑的可靠性，但没有一个频率能抑制BG中的所有病理活动。然而，我们的严格研究使我们找到了一种涉及低频多输入相移DBS的新颖DBS策略，该策略成功抑制了所有BG核的病理症状，并实现了可靠的丘脑中继。神经恢复对于模型参数的变化（从早期到晚期PD阶段表征）仍然保持稳健。

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