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首页> 外文期刊>Journal of Computational Neuroscience >Modified thalamocortical model: A step towards more understanding of the functional contribution of astrocytes to epilepsy
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Modified thalamocortical model: A step towards more understanding of the functional contribution of astrocytes to epilepsy

机译：改良的丘脑皮质模型：迈向进一步了解星形胶质细胞对癫痫的功能性贡献的一步

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摘要

It is evident that the cortex plays a primary role in seizure generation. At the same time, various experimental results clearly confirm that thalamic neurons are also actively involved in seizure generation and spreading. On the other hand, recent neurophysiologic findings suggest that astrocytes regulate dynamically the synaptic activity in neuronal networks. Therefore, in the present study, the thalamocortical neural population model (TCPM) is modified by embedding into the model the functional role of astro- cytes in the regulation of synaptic transmission. Using the modified TCPM (MTCPM) we examined the hypothesis that one of the possible causes of neural hypersynchro-nization is the dysfunction of astrocytes in the regulatory feedback loop. Then, two MTCPMs are coupled via excitatory synapses and the astrocytes are also coupled together through gap junctions. Utilizing the MTCPM and CMTCPM, the transition from normal to malfunctioned states is analyzed using a dynamical system approach. In this way, the hypothesis is investigated and it is demonstrated that the healthy astrocytes provide feedback control to regulate neural activity. That is, the astrocytes compensate to a large extent variations in the coupling between neural populations and maintain the balance between the excitation and inhibition levels. However, the malfunctioned astrocytes are no longer able to regulate and/or compensate the excessive increase of the inter-population coupling strength. As a consequence, disruption of the signaling function of astrocytes could contribute to the neuronal hyperexcitability and generating epileptiform activity. These results suggest that astrocytes might be one of the potential targets for the treatment of epilepsy.
机译：显然，皮质在癫痫发作中起主要作用。同时，各种实验结果清楚地证明，丘脑神经元也积极参与癫痫发作的产​​生和扩散。另一方面，最近的神经生理学发现表明星形胶质细胞动态调节神经元网络中的突触活动。因此，在本研究中，通过将星形胶质细胞在调节突触传递中的功能作用嵌入到模型中来修改丘脑皮质神经种群模型（TCPM）。使用修改后的TCPM（MTCPM），我们检查了以下假设：神经过度同步化的可能原因之一是调节反馈回路中的星形胶质细胞功能障碍。然后，两个MTCPM通过兴奋性突触耦合，星形胶质细胞也通过间隙连接耦合在一起。利用MTCPM和CMTCPM，可以使用动态系统方法分析从正常状态到故障状态的转变。通过这种方式，对假设进行了研究，并证明了健康的星形胶质细胞可提供反馈控制来调节神经活动。也就是说，星形胶质细胞在很大程度上补偿了神经种群之间的耦合变化，并维持了激发和抑制水平之间的平衡。但是，发生故障的星形胶质细胞不再能够调节和/或补偿种群间偶联强度的过度增加。结果，星形胶质细胞信号功能的破坏可能有助于神经元过度兴奋并产生癫痫样活动。这些结果表明星形胶质细胞可能是治疗癫痫的潜在目标之一。

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  • 来源
    《Journal of Computational Neuroscience》 |2012年第2期|p.285-299|共15页
  • 作者

    Mahmood Amiri; Fariba Bahrami; Mahyar Janahmadi;

  • 作者单位

    Department of Electrical engineering, Razi University, Kermanshah, Iran,School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran,Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;

    CIPCE, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran;

    Neuroscience Research Center and Department of Physiology, Medical School, Shahid Beheshti Medical Sciences University, Tehran, Iran;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    astrocytes; thalamocortical model; epilepsy; functional modeling;

    机译：星形胶质细胞丘脑皮质模型癫痫;功能建模;

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