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On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons

机译:关于CA1锥体神经元突增动力学中去极化阻滞的潜在机制

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Under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. This is a robust effect that is not usually explored in experiments or explicitly implemented or tested in models. However, the range of current strength needed for a depolarization block could be easily reached with a random background activity of only a few hundred excitatory synapses. Depolarization block may thus be an important property of neurons that should be better characterized in experiments and explicitly taken into account in models at all implementation scales. Here we analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specific ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to a depolarization block. We suggest that this can be one of the rate-limiting mechanisms protecting a CA1 neuron from excessive spiking activity.
机译:在持续增加强度的持续输入电流下,神经元最终停止发射,进入去极化阻滞。这是一种健壮的效果,通常不会在实验中进行探索,也不会在模型中明确实现或测试。但是,只需几百个兴奋性突触的随机背景活动就可以轻松达到去极化阻滞所需的电流强度范围。因此,去极化阻滞可能是神经元的重要属性,应在实验中更好地表征,并在所有实施规模的模型中明确考虑。在这里,我们分析了使用相同离子电流集的CA1锥体神经元模型的尖峰动力学,既可以进行精确的形态重建,也可以将其还原为单个小室。结果显示了重现实验结果所需的特定离子通道特性和动力学,以及它们之间的相互作用如何极大地调节神经元动力学和导致去极化阻滞的输入电流范围。我们建议这可能是保护CA1神经元免于过度加标活动的限速机制之一。

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