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首页> 外文期刊>Journal of Computational Neuroscience >Phase-resetting curve determines how BK currents affect neuronal firing
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Phase-resetting curve determines how BK currents affect neuronal firing

机译：相位重置曲线确定BK电流如何影响神经元放电

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摘要

BK channels are large conductance potassium channels gated by calcium and voltage. Paradoxically, blocking these channels has been shown experimentally to increase or decrease the firing rate of neurons, depending on the neural subtype and brain region. The mechanism for how this current can alter the firing rates of different neurons remains poorly understood. Using phase-resetting curve (PRC) theory, we determine when BK channels increase or decrease the firing rates in neural models. The addition of BK currents always decreases the firing rate when the PRC has only a positive region. When the PRC has a negative region (type II), BK currents can increase the firing rate. The influence of BK channels on firing rate in the presence of other conductances, such as I_m and I_h, as well as with different amplitudes of depolarizing input, were also investigated. These results provide a formal explanation for the apparently contradictory effects of BK channel antagonists on firing rates.
机译：BK通道是由钙和电压控制的大电导钾通道。矛盾的是，实验表明，阻断这些通道可增加或降低神经元的放电速度，具体取决于神经亚型和大脑区域。这种电流如何改变不同神经元放电速率的机制仍然知之甚少。使用相位重设曲线（PRC）理论，我们确定BK通道何时增加或减少神经模型中的放电率。当中华人民共和国只有一个正区域时，增加BK电流总是会降低点火速率。当PRC具有负区域（II型）时，BK电流可以提高点火速度。还研究了在存在其他电导（例如I_m和I_h）以及具有不同幅度的去极化输入的情况下，BK通道对发射速率的影响。这些结果为BK通道拮抗剂对射速的明显矛盾效应提供了正式解释。

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