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首页> 外文期刊>Journal of Computational Neuroscience >Asymmetric electrotonic coupling between the soma and dendrites alters the bistable firing behaviour of reduced models
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Asymmetric electrotonic coupling between the soma and dendrites alters the bistable firing behaviour of reduced models

机译：体和树突之间的不对称电声耦合改变了简化模型的双稳态激发行为

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The goal of the study was to investigate the influence of asymmetric coupling, between the soma and dendrites, on the nonlinear dynamic behaviour of a two-compartment model. We used a recently published method for generating reduced two-compartment models that retain the asymmetric coupling of anatomically reconstructed motor neurons. The passive input-output relationship of the asymmetrically coupled model was analytically compared to the symmetrically coupled case. Predictions based on the analytic comparison were tested using numerical simulations. The simulations evaluated the nonlinear dynamics of the models as a function of coupling parameters. Analytical results showed that the input resistance at the dendrite of the asymmetric model was directly related to the degree of coupling asymmetry. In contrast, a comparable symmetric model had identical input resistances at both the soma and dendrite regardless of coupling strength. These findings lead to predictions that variations in dendritic excitability, subsequent to changes in input resistance, might change the current threshold and onset timing of the plateau potential generated in the dendrite. Since the plateau potential underlies bistable firing, these results further predicted that asymmetric coupling might alter nonlinear (i.e. bistable) firing patterns. The numerical simulations supported analytical predictions, showing that the fully bistable firing pattern of the asymmetric model depended on the degree of coupling asymmetry and its correlated dendritic excitability. The physiological property of asymmetric coupling plays an important role in generating and stabilizing the bistability of motor neurons by interacting with the excitability of dendritic branches.
机译：该研究的目的是研究体室和树突之间的不对称耦合对两室模型的非线性动力学行为的影响。我们使用了一种最新发布的方法来生成简化的两室模型，该模型保留了解剖上重建的运动神经元的不对称耦合。将非对称耦合模型的被动输入-输出关系与对称耦合情况进行了分析比较。使用数值模拟测试了基于分析比较的预测。仿真评估了模型的非线性动力学随耦合参数的变化。分析结果表明，不对称模型在枝晶处的输入电阻与耦合不对称程度直接相关。相反，无论耦合强度如何，可比较的对称模型在体部和枝晶处都具有相同的输入电阻。这些发现导致预测，在输入电阻变化之后，树突状兴奋性的变化可能会改变电流阈值和枝晶中产生的平台电位的起始时间。由于平台势是双稳态点火的基础，因此这些结果进一步预测了非对称耦合可能会改变非线性（即双稳态）点火模式。数值模拟支持分析预测，表明非对称模型的完全双稳态激发模式取决于偶合不对称程度及其相关的树枝状激发性。不对称偶联的生理特性通过与树突分支的兴奋性相互作用，在产生和稳定运动神经元的双稳态中起重要作用。

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