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首页> 外文期刊>Journal of Computational Neuroscience >A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning
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A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning

机译：小脑前庭眼眼反射学习中部分记忆转移的突触机制的计算研究

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There is a debate regarding whether motor memory is stored in the cerebellar cortex, or the cerebellar nuclei, or both. Memory may be acquired in the cortex and then be transferred to the cerebellar nuclei. Based on a dynamical system modeling with a minimal set of variables, we theoretically investigated possible mechanisms of memory transfer and consolidation in the context of vestibulo-ocular reflex learning. We tested different plasticity rules for synapses in the cerebellar nuclei and took robustness of behavior against parameter variation as the criterion of plausibility of a model variant. In the most plausible scenarios, mossy-fiber nucleus-neuron synapses or Purkinje-cell nucleus-neuron synapses are plastic on a slow time scale and store permanent memory, whose content is passed from the cerebellar cortex storing transient memory. In these scenarios, synaptic strengths are potentiated when the mossy-fiber afferents to the nuclei are active during a pause in Purkinje-cell activities. Furthermore, assuming that mossy fibers create a limited variety of signals compared to parallel fibers, our model shows partial memory transfer from the cortex to the nuclei.
机译：关于运动记忆是否存储在小脑皮层或小脑核或两者中存在争议。可以在皮质中获得记忆，然后将其转移到小脑核。基于具有最小变量集的动力学系统建模，我们在理论上研究了前庭眼反射学习中记忆转移和巩固的可能机制。我们测试了小脑核突触的不同可塑性规则，并将针对参数变化的行为鲁棒性作为模型变异的合理性标准。在最可能的情况下，苔藓纤维核-神经元突触或浦肯野细胞核-神经元突触在较慢的时间尺度上是可塑性的，并存储永久性记忆，其内容从小脑皮层传递而存储瞬态记忆。在这些情况下，当浦肯野细胞活动暂停期间，向核的苔藓纤维传入神经活跃时，突触强度就会增强。此外，假设与平行纤维相比，长满苔藓的纤维产生的信号种类有限，我们的模型显示了从皮质到细胞核的部分记忆转移。

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