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首页> 外文期刊>Journal of Computational Neuroscience >Spike-frequency adaptation generates intensity invariance in a primary auditory interneuron
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Spike-frequency adaptation generates intensity invariance in a primary auditory interneuron

机译：尖峰频率适应在初级听觉神经元中产生强度不变性

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摘要

Adaptation of the spike-frequency response to constant stimulation, as observed on various timescales in many neurons, reflects high-pass filter properties of a neuron's transfer function. Adaptation in general, however, is not sufficient to make a neuron's response independent of the mean intensity of a sensory stimulus, since low frequency components of the stimulus are still transmitted, although with reduced gain. We here show, based on an analytically tractable model, that the response of a neuron is intensity invariant, if the fully adapted steady-state spike-frequency response to constant stimuli is independent of stimulus intensity. Electrophysiological recordings from the AN1, a primary auditory interneuron of crickets, show that for intensities above 60 dB SPL (sound pressure level) the AN1 adapted with a time-constant of ~ 40 ms to a steady-state firing rate of ~ 100 Hz. Using identical random amplitude-modulation stimuli we verified that the ANl's spike-frequency response is indeed invariant to the stimulus' mean intensity above 60 dB SPL. The transfer function of the AN1 is a band pass, resulting from a high-pass filter (cutoff frequency at 4 Hz) due to adaptation and a low-pass filter (100 Hz) determined by the steady-state spike frequency. Thus, fast spike-frequency adaptation can generate intensity invariance already at the first level of neural processing.
机译：在许多神经元的不同时间尺度上观察到的对恒定刺激的尖峰频率响应的适应性反映了神经元传递函数的高通滤波器特性。但是，一般来说，适应不足以使神经元的反应独立于感觉刺激的平均强度，因为尽管增益降低，​​但刺激的低频成分仍在传播。我们在此基于可分析的易处理模型显示，如果对恒定刺激的完全适应的稳态峰值频率响应与刺激强度无关，则神经元的响应是强度不变的。 1的主要听觉神经元AN1的电生理记录表明，对于强度高于60 dB SPL（声压级）的AN1，其时间常数约为40 ms，其稳态发射速率约为100 Hz。使用相同的随机幅度调制刺激，我们验证了AN1的尖峰频率响应确实对刺激的平均强度高于60 dB SPL不变。 AN1的传递函数是一个带通，它是由于自适应产生的高通滤波器（截止频率为4 Hz）和由稳态尖峰频率确定的低通滤波器（100 Hz）引起的。因此，快速的尖峰频率自适应可以在神经处理的第一级产生强度不变性。

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