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首页> 外文期刊>Journal of Computational Neuroscience >Influence of frequency and temperature on the mechanisms of nerve conduction block induced by high-frequency biphasic electrical current
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Influence of frequency and temperature on the mechanisms of nerve conduction block induced by high-frequency biphasic electrical current

机译：频率和温度对高频双相电流诱导的神经传导阻滞机制的影响

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摘要

The influences of stimulation frequency and temperature on mechanisms of nerve conduction block induced by high-frequency biphasic electrical current were investigated using a lumped circuit model of the myelinated axon based on Schwarz and Eikhof (SE) equations. The simulation analysis showed that a temperature-frequency relationship was determined by the axonal membrane dynamics (i.e. how fast the ion channels can open or close.). At a certain temperature, the axonal conduction block always occurred when the period of biphasic stimulation was smaller than the action potential duration (APD). When the temperature decreased from 37 to 15℃, the membrane dynamics slowed down resulting in an APD increase from 0.4 to 2.4 ms accompanied by a decrease in the minimal blocking frequency from 4 to 0.5 kHz. The simulation results also indicated that as the stimulation frequency increased the mechanism of conduction block changed from a cathodal/anodal block to a block dependent upon continuous activation of potassium channels. Understanding the interaction between the minimal blocking frequency and temperature could promote a better understanding of the mechanisms of high frequency induced axonal conduction block and the clinical application of this method for blocking nerve conduction.
机译：基于基于Schwarz和Eikhof（SE）方程的髓鞘轴突集总电路模型，研究了刺激频率和温度对高频双相电流诱导的神经传导阻滞机制的影响。仿真分析表明，温度-频率关系由轴突膜动力学（即离子通道打开或关闭的速度）决定。在一定温度下，当双相刺激的周期小于动作电位持续时间（APD）时，总是发生轴突传导阻滞。当温度从37℃降低到15℃时，膜动力学减慢，导致APD从0.4毫秒增加到2.4毫秒，同时最小阻断频率从4 kHz降低到0.5 kHz。仿真结果还表明，随着刺激频率的增加，传导阻滞的机理从阴极/阳极阻滞改变为依赖于钾通道持续激活的阻滞。了解最小阻断频率和温度之间的相互作用可以促进对高频诱导的轴突传导阻断机制的更好理解，以及该方法阻断神经传导的临床应用。

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