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首页> 外文期刊>Journal of Computational Neuroscience >A modeling comparison of projection neuron- and n euro modulator-elicited oscillations in a central pattern generating network
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A modeling comparison of projection neuron- and n euro modulator-elicited oscillations in a central pattern generating network

机译：中央模式生成网络中投影神经元和n欧元调制器引起的振荡的模型比较

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Many central pattern generating networks are influenced by synaptic input from modulatory projection neurons. The network response to a projection neuron is sometimes mimicked by bath applying the neuronally-released modulator, despite the absence of network interactions with the projection neuron. One interesting example occurs in the crab stomatogastric ganglion (STG), where bath applying the neuropeptide pyrokinin (PK) elicits a gastric mill rhythm which is similar to that elicited by the projection neuron modulatory commissural neuron 1 (MCN1), despite the absence of PK in MCN1 and the fact that MCN1 is not active during the PK-elicited rhythm. MCN1 terminals have fast and slow synaptic actions on the gastric mill network and are presynaptically inhibited by this network in the STG. These local connections are inactive in the PK-elicited rhythm, and the mechanism underlying this rhythm is unknown. We use mathematical and biophysically-realistic modeling to propose potential mechanisms by which PK can elicit a gastric mill rhythm that is similar to the MCN1-elicited rhythm. We analyze slow-wave network oscillations using simplified mathematical models and, in parallel, develop biophysically-realistic models that account for fast, action potential-driven oscillations and some spatial structure of the network neurons. Our results illustrate how the actions of bath-applied neuromodulators can mimic those of descending projection neurons through mathematically similar but physiologically distinct mechanisms.
机译：许多中央模式生成网络受到来自调制投影神经元的突触输入的影响。尽管不存在与投影神经元的网络交互作用，但有时通过应用神经元释放的调节剂进行沐浴可以模仿对投影神经元的网络响应。一个有趣的例子发生在螃蟹的胃胃神经节（STG）中，尽管没有PK，但应用神经肽焦蛋白（PK）的浴引起胃磨节律，类似于投射神经元调节性连合神经元1（MCN1）引起的胃节律。在MCN1中，MCN1在PK引起的节律中不活跃。 MCN1终端在胃磨网上具有快速和缓慢的突触作用，并在STG中被该网络预先突触抑制。这些局部连接在PK引起的节律中是无效的，并且该节律的潜在机制尚不清楚。我们使用数学和生物物理学上的逼真模型来提出潜在的机制，通过该机制PK可以引起类似于MCN1引起的节奏的胃磨节律。我们使用简化的数学模型分析慢波网络振荡，并同时开发生物物理逼真的模型，这些模型说明了快速，动作电位驱动的振荡和网络神经元的某些空间结构。我们的研究结果说明了沐浴应用的神经调节剂的作用如何通过数学上类似但生理上不同的机制模仿下降的投射神经元的作用。

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