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首页> 外文期刊>Journal of Computational Neuroscience >Estimation of population firing rates and current source densities from laminar electrode recordings
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Estimation of population firing rates and current source densities from laminar electrode recordings

机译：从层状电极记录估算种群发射率和电流源密度

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摘要

This model study investigates the validity of methods used to interpret linear (laminar) mul-tielectrode recordings. In computer experiments extracellular potentials from a synaptically activated population of about 1,000 pyramidal neurons are calculated using biologically realistic compartmental neuron models combined with electrostatic forward modeling. The somas of the pyramidal neurons are located in a 0.4 mm high and wide columnar cylinder, mimicking a stimulus-evoked layer-5 population in a neocortical column. Current-source density (CSD) analysis of the low-frequency part (<500 Hz) of the calculated potentials (local field potentials, LFP) based on the 'inverse' CSD method is, in contrast to the 'standard' CSD method, seen to give excellent estimates of the true underlying CSD. The high-frequency part (>750 Hz) of the potentials (multi-unit activity, MUA) is found to scale approximately as the population firing rate to the power 3/4 and to give excellent estimates of the underlying population firing rate for trial-averaged data. The MUA signal is found to decay much more sharply outside the columnar populations than the LFP.
机译：该模型研究调查了用于解释线性（层状）多电极记录的方法的有效性。在计算机实验中，使用生物学上现实的区室神经元模型与静电正向建模相结合，计算了约1,000个锥体神经元的突触激活种群的细胞外电位。锥体神经元的体细胞位于0.4毫米高，宽的圆柱状圆柱体中，模仿了新皮质圆柱中刺激诱发的5层种群。与“标准” CSD方法相比，基于“逆” CSD方法对计算出的电势（局部场电势，LFP）的低频部分（<500 Hz）进行电流源密度（CSD）分析是，可以很好地估算出真正的潜在CSD。发现电位的高频部分（> 750 Hz）（多单位活动，MUA）大约随着人口射击率达到幂3/4而缩放，并且可以很好地估计潜在的人口射击率以进行试验平均数据。发现MUA信号在柱状种群外的衰减要比LFP大得多。

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