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首页> 外文期刊>Journal of Computational Neuroscience >Spike timing dependent plasticity promotes synchrony of inhibitory networks in the presence of heterogeneity
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Spike timing dependent plasticity promotes synchrony of inhibitory networks in the presence of heterogeneity

机译：穗时间依赖性可塑性在异质性存在时促进抑制网络的同步

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Recently Haas et al. (J Neurophysiol 96: 3305-3313,2006), observed a novel form of spike timing dependent plasticity (iSTDP) in GABAergic synaptic couplings in layer II of the entorhinal cortex. Depending on the relative timings of the presynaptic input at time t_(pre) and the postsynaptic excitation at time t_(post), the synapse is strengthened (Δt = t_(post) - t_(pre) > 0) or weakened (Δt < 0). The temporal dynamic range of the observed STDP rule was found to lie in the higher gamma frequency band (≥40 Hz), a frequency range important for several vital neuronal tasks. In this paper we study the function of this novel form of iSTDP in the synchronization of the inhibitory neuronal network. In particular we consider a network of two unidirec-tionally coupled interneurons (UCI) and two mutually coupled interneurons (MCI), in the presence of heterogeneity in the intrinsic firing rates of each coupled neuron. Using the method of spike time response curve (STRC), we show how iSTDP influences the dynamics of the coupled neurons, such that the pair synchronizes under moderately large heterogeneity in the firing rates. Using the general properties of the STRC for a Type-1 neuron model (Ermentrout, Neural Comput 8:979-1001, 1996) and the observed iSTDP we determine conditions on the initial configuration of the UCI network that would result in 1:1 in-phase synchrony between the two coupled neurons. We then demonstrate a similar enhancement of synchrony in the MCI with dynamic synaptic modulation. For the MCI we also consider heterogeneity introduced in the network through the synaptic parameters: the synaptic decay time of mutual inhibition and the self inhibition synaptic strength. We show that the MCI exhibits enhanced synchrony in the presence of all the above mentioned sources of heterogeneity and the mechanism for this enhanced synchrony is similar to the case of the UCI.
机译：最近，哈斯等。 （J Neurophysiol 96：3305-3313，2006），观察到内嗅皮层II层中的GABA能突触偶合中一种新型的依赖于时序定时的可塑性（iSTDP）。根据时间t_（pre）的突触前输入和时间t_（post）的突触后激发的相对时序，突触会增强（Δt= t_（post）-t_（pre）> 0）或减弱（Δt< 0）。发现所观察到的STDP规则的时间动态范围位于较高的伽马频段（≥40 Hz），该频率范围对于一些重要的神经元任务很重要。在本文中，我们研究了这种新型iSTDP在抑制性神经元网络同步中的功能。特别是，在每个耦合神经元的内在激发速率存在异质性的情况下，我们考虑两个单向耦合中枢神经元（UCI）和两个相互耦合中枢神经元（MCI）组成的网络。使用尖峰时间响应曲线（STRC）的方法，我们展示了iSTDP如何影响耦合神经元的动力学，从而使该对在发射速率的中等较大异质性下同步。使用类型1神经元模型（Ermentrout，Neural Comput 8：979-1001，1996）的STRC的一般属性和观察到的iSTDP，我们确定UCI网络初始配置的条件，该条件会导致1：1两个耦合神经元之间的相位同步。然后，我们演示了MCI与动态突触调制的同步性的类似增强。对于MCI，我们还考虑通过突触参数在网络中引入的异质性：相互抑制的突触衰减时间和自抑制突触强度。我们表明，在所有上述异构源的存在下，MCI表现出增强的同步性，并且这种增强的同步性机制类似于UCI的情况。

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