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首页> 外文期刊>Journal of Computational Neuroscience >Initiation and propagation of a neuronal intracellular calcium wave
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Initiation and propagation of a neuronal intracellular calcium wave

机译：神经元细胞内钙波的起始和传播

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The ability to image calcium movement within individual neurons inspires questions of functionality including whether calcium entry into the nucleus is related to genetic regulation for phenomena such as long term potentiation. Calcium waves have been initiated in hippocampal pyramidal cells with glutmatergic signals both in the presence and absence of back propagating action potentials (BPAPs). The dendritic sites of initiation of these calcium waves within about 100 μm of the soma are thought to be localized near oblique junctions. Stimulation of synapses on oblique dendrites leads to production of inositol 1,4,5-trisphosphate (IP_3) which diffuses to the apical dendrite igniting awaiting IP3 receptors (IP_3RS) and initiating and propagating catalytic calcium release from the endoplasmic retic-ulum. We construct a reduced mathematical system which accounts for calcium wave initiation and propagation due to elevated IP_3. Inhomogeneity in IP_3 distribution is responsible for calcium wave initiation versus subthreshold or spatially uniform suprathreshold activation. However, the likelihood that a calcium wave is initiated does not necessarily increase with more calcium entering from BPAPs. For low transient synaptic stimuli, timing between IP3 generation and BPAPs is critical for calcium wave initiation. We also show that inhomogeneity in IP3R density can account for calcium wave directionality. Simulating somatic muscarinic receptor production of IP_3, we can account for the critical difference between calcium wave entry into the soma and failure to do so.
机译：对单个神经元内钙运动进行成像的能力引发了功能性问题，包括钙是否进入细胞核是否与诸如长期增强等现象的遗传调控有关。在存在和不存在反向传播动作电位（BPAP）的情况下，海马锥体细胞均以谷氨酸能信号引发钙波。这些钙波在大约100μm的体细胞内引发的树突状位点被认为位于斜交点附近。斜突状突触的刺激导致肌醇1,4,5-三磷酸（IP_3）的产生，扩散到顶端的树突中，点燃等待IP3受体（IP_3RS），并引发和传播内质网中钙的催化释放。我们构建了一个简化的数学系统，该系统解释了由于IP_3升高而引起的钙波引发和传播。 IP_3分布中的不均匀性是钙波引发与阈下或空间上均匀的阈上激活之间的关系。但是，随着更多的钙从BPAP进入，引发钙波的可能性并不一定会增加。对于低瞬态突触刺激，IP3生成和BPAP之间的时序对于钙波启动至关重要。我们还显示IP3R密度的不均匀性可以解释钙波的方向性。模拟IP_3的体毒蕈碱受体的产生，我们可以解释钙波进入体细胞与失败之间的关键差异。

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