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A Computational Model For Motor Pattern Switching Between Taste-induced Ingestion And Rejection Oromotor Behaviors

机译:味觉摄入与拒绝冲动行为之间的运动模式转换的计算模型

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摘要

The mechanism of switching activity patterns in a central pattern generator is fundamental to the generation of diverse motor behaviors. Based on what is known about a brainstem substrate mediating the oral components of ingestion and rejection, we use computational techniques to construct a hypothetical multifunctional network that switches between the motor outputs of ingestion (licking) and rejection (gaping). The network was constructed using single-compartment conductance-based models for individual neurons based on Hodgkin-Huxley formalism. Using a fast-slow reduction and geometric analysis we describe a mechanism for pattern switching between licks and gapes. The model supports the hypothesis that a single configuration of network connections can produce both activity patterns. It further predicts that prolonged inhibition of some network neurons could lead to a switch in network activity from licks to gapes.
机译:中央模式生成器中的活动模式切换机制是产生各种运动行为的基础。基于已知的介导摄取和排斥的口腔成分的脑干基质,我们使用计算技术构建了一个假设的多功能网络,该网络在摄取(舔)和排斥(张开)的运动输出之间切换。该网络是根据霍奇金-赫克斯利形式主义,使用基于单室电导的单个神经元模型构建的。使用快速慢速缩小和几何分析,我们描述了一种在舔和间隙之间进行图案切换的机制。该模型支持以下假设:网络连接的单个配置可以产生两种活动模式。它进一步预测,对某些网络神经元的长期抑制可能导致网络活动从舔到间隙的转变。

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