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首页> 外文期刊>Journal of Computational Neuroscience >An integrate-and-fire model for synchronized bursting in a network of cultured cortical neurons
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An integrate-and-fire model for synchronized bursting in a network of cultured cortical neurons

机译：用于培养的皮质神经元网络中的同步爆发的整合射击模型

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It has been suggested that spontaneous synchronous neuronal activity is an essential step in the formation of functional networks in the central nervous system. The key features of this type of activity consist of bursts of action potentials with associated spikes of elevated cytoplas-mic calcium. These features are also observed in networks of rat cortical neurons that have been formed in culture. Experimental studies of these cultured networks have led to several hypotheses for the mechanisms underlying the observed synchronized oscillations. In this paper, bursting integrate-and-fire type mathematical models for regular spiking (RS) and intrinsic bursting (IB) neurons are introduced and incorporated through a small-world connection scheme into a two-dimensional excitatory network similar to those in the cultured network. This computer model exhibits spontaneous synchronous activity through mechanisms similar to those hypothesized for the cultured experimental networks. Traces of the membrane potential and cytoplasmic calcium from the model closely match those obtained from experiments. We also consider the impact on network behavior of the IB neurons, the geometry and the small world connection scheme.
机译：已经提出，自发的同步神经元活动是中枢神经系统中功能网络形成的重要步骤。这种活动的主要特征包括动作电位的爆发和相关的细胞质钙水平升高峰值。这些特征还在培养物中形成的大鼠皮质神经元网络中观察到。这些培养网络的实验研究导致观察到的同步振荡基础的机制的几个假设。在本文中，介绍了用于常规尖峰（RS）和固有突发（IB）神经元的突发积分和发射型数学模型，并通过小世界连接方案将其合并到类似于培养的二维兴奋网络中。网络。该计算机模型通过类似于为培养的实验网络假设的机制表现出自发的同步活动。该模型的膜电位和细胞质钙的痕迹与实验获得的痕迹非常匹配。我们还考虑了对IB神经元的网络行为，几何形状和小世界连接方案的影响。

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