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首页> 外文期刊>Journal of Computational Neuroscience >The Possible Role of Spike Patterns in Cortical Information Processing
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The Possible Role of Spike Patterns in Cortical Information Processing

机译：峰值模式在皮质信息处理中的可能作用

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When the same visual stimulus is presented across many trials, neurons in the visual cortex receive stimulus-related synaptic inputs that are reproducible across trials (S) and inputs that are not (N). The variability of spike trains recorded in the visual cortex and their apparent lack of spike-to-spike correlations beyond that implied by firing rate fluctuations, has been taken as evidence for a low S/N ratio. A recent re-analysis of in vivo cortical data revealed evidence for spike-to-spike correlations in the form of spike patterns. We examine neural dynamics at a higher S/N in order to determine what possible role spike patterns could play in cortical information processing. In vivo-like spike patterns were obtained in model simulations. Superpositions of multiple sinusoidal driving currents were especially effective in producing stable long-lasting patterns. By applying current pulses that were either short and strong or long and weak, neurons could be made to switch from one pattern to another. Cortical neurons with similar stimulus preferences are located near each other, have similar biophysical properties and receive a large number of common synaptic inputs. Hence, recordings of a single neuron across multiple trials are usually interpreted as the response of an ensemble of these neurons during one trial. In the presence of distinct spike patterns across trials there is ambiguity in what would be the corresponding ensemble, it could consist of the same spike pattern for each neuron or a set of patterns across neurons. We found that the spiking response of a neuron receiving these ensemble inputs was determined by the spike-pattern composition, which, in turn, could be modulated dynamically as a means for cortical information processing.
机译：当在许多试验中都显示相同的视觉刺激时，视觉皮层中的神经元会收到与刺激相关的突触输入，这些输入在各个试验中均可以再现（S），而在所有试验中均不可再现（N）。视皮层中记录的尖峰序列的变异性以及它们明显缺乏尖峰与尖峰的相关性超出了发射速率波动所暗示的水平，已被视为低信噪比的证据。最近对体内皮层数据的重新分析揭示了以尖峰模式形式出现尖峰与尖峰相关性的证据。为了确定峰值模式在皮层信息处理中可能发挥的作用，我们在较高的信噪比下检查了神经动力学。在模型模拟中获得了类似体内的尖峰模式。多个正弦驱动电流的叠加在产生稳定的持久图案方面特别有效。通过施加短而强或长而弱的电流脉冲，可以使神经元从一种模式切换到另一种模式。具有相似刺激偏好的皮质神经元彼此靠近，具有相似的生物物理特性，并接受大量常见的突触输入。因此，多次试验中单个神经元的记录通常被解释为一次试验中这些神经元整体的反应。在整个试验中存在明显的峰值模式的情况下，相应的整体会有歧义，它可能由每个神经元的相同峰值模式或整个神经元的一组模式组成。我们发现，接收到这些合奏输入的神经元的尖峰响应由尖峰模式组成决定，而尖峰模式组成又可以动态地进行调制，作为皮层信息处理的一种手段。

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