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首页> 外文期刊>Journal of Computational Neuroscience >Modeling the Spontaneous Activity of the Auditory Cortex
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Modeling the Spontaneous Activity of the Auditory Cortex

机译：模拟听觉皮层的自发活动

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We present a rate model of the spontaneous activity in the auditory cortex, based on synaptic depression. A Stochastic integro-differential system of equations is derived and the analysis reveals two main regimes. The first regime corresponds to a normal activity. The second regime corresponds to epileptic spiking. A detailed analysis of each regime is presented and we prove in particular that synaptic depression stabilizes the global cortical dynamics. The transition between the two regimes is induced by a change in synaptic connectivity: when the overall connectivity is strong enough, an epileptic activity is spontaneously generated. Numerical simulations confirm the predictions of the theoretical analysis. In particular, our results explain the transition from normal to epileptic regime which can be induced in rats auditory cortex, following a specific pairing protocol. A change in the cortical maps reorganizes the synaptic connectivity and this transition between regimes is accounted for by our model. We have used data from recording experiments to fit synaptic weight distributions. Simulations with the fitted distributions are qualitatively similar to the real EEG recorded in vivo during the experiments. We conclude that changes in the synaptic weight function in our model, which affects excitatory synapses organization and reproduces the changes in cortical map connectivity can be understood as the main mechanism to explain the transitions of the EEG from the normal to the epileptic regime in the auditory cortex.
机译：我们提出了一种基于突触抑制的听觉皮层自发活动的速率模型。推导了一个随机积分微分方程组，该分析揭示了两种主要形式。第一方案对应于正常活动。第二种方案对应于癫痫发作。提出了每个方案的详细分析，我们特别证明，突触抑制稳定了整体皮层动力学。两种机制之间的过渡是由突触连接性的变化引起的：当整体连接性足够强时​​，会自发产生癫痫活动。数值模拟证实了理论分析的预测。特别地，我们的结果解释了遵循特定的配对规程可以在大鼠听觉皮层中诱导的从正常状态向癫痫状态的转变。皮质图谱的改变重新组织了突触的连通性，并且这种模式之间的过渡由我们的模型解释。我们使用了来自记录实验的数据来拟合突触重量分布。具有拟合分布的模拟在质量上类似于实验期间在体内记录的真实EEG。我们得出的结论是，在我们的模型中，突触权重功能的变化会影响兴奋性突触的组织并重现皮质图连接性的变化，这可以理解为解释脑电图从听觉正常向癫痫过渡的主要机制。皮层。

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