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首页> 外文期刊>Journal of Computational Neuroscience >The Activity Phase of Postsynaptic Neurons in a Simplified Rhythmic Network
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The Activity Phase of Postsynaptic Neurons in a Simplified Rhythmic Network

机译：简化节律网络中的突触后神经元的活动阶段。

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摘要

Many inhibitory rhythmic networks produce activity in a range of frequencies. The relative phase of activity between neurons in these networks is often a determinant of the network output. This relative phase is determined by the interaction between synaptic inputs to the neurons and their intrinsic properties. We show, in a simplified network consisting of an oscillator inhibiting a follower neuron, how the interaction between synaptic depression and a transient potassium current in the follower neuron determines the activity phase of this neuron. We derive a mathematical expression to determine at what phase of the oscillation the follower neuron becomes active. This expression can be used to understand which parameters determine the phase of activity of the follower as the frequency of the oscillator is changed. We show that in the presence of synaptic depression, there can be three distinct frequency intervals, in which the phase of the follower neuron is determined by different sets of parameters. Alternatively, when the synapse is not depressing, only one set of parameters determines the phase of activity at all frequencies.
机译：许多抑制性节奏网络在一定频率范围内产生活性。这些网络中神经元之间活动的相对阶段通常是网络输出的决定因素。该相对相位由神经元的突触输入与其固有特性之间的相互作用决定。我们显示，在一个由抑制跟随神经元的振荡器组成的简化网络中，跟随神经元中突触抑制和瞬时钾电流之间的相互作用如何确定该神经元的活动阶段。我们导出一个数学表达式，以确定跟随者神经元在振荡的哪个阶段变得活跃。该表达式可用于理解随着振荡器频率的变化，哪些参数确定跟随器的活动阶段。我们显示，在突触抑制的存在下，可以存在三个不同的频率间隔，其中跟随者神经元的相位由不同的参数集确定。可替代地，当突触不压抑时，只有一组参数确定在所有频率下的活动阶段。

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