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Type I Burst Excitability

机译：I型爆发兴奋性

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摘要

We introduce the concept of "type Ⅰ burst excitability", which is a generalization of the "normal" excitability that is well-known in cardiac and neural systems. We demonstrate this type of burst excitability in a specific model system, a pyramidal cell from the electrosensory lateral line lobe of the weakly electric fish Apteronotus leptorhynchus. As depolarizing current is increased, a saddle-node bifurcation of periodic orbits occurs, which separates tonic and burst activity. This bifurcation is responsible for the excitable nature of the system, and is the basis for the "type Ⅰ" designation. We verify the existence of this transition from in vitro recordings of a number of actual pyramidal cells. A scaling relationship between the magnitude and duration of a current pulse required to induce a burst is derived. We also observe this type of burst excitability and the scaling relationships in a multicompartmental model that is driven by realistic stochastic synaptic inputs mimicking sensory input. We conclude by discussing the relevance of burst excitability to communication between weakly electric fish.
机译：我们介绍“Ⅰ型爆发性兴奋性”的概念，它是在心脏和神经系统中众所周知的“正常”兴奋性的概括。我们在特定的模型系统（从弱电鱼Apteronotus leptorhynchus的电感应侧线波瓣中形成的锥体细胞）中展示了这种类型的爆发式兴奋性。随着去极化电流的增加，发生周期性轨道的鞍形节点分叉，这将强音和爆发活动分开。这种分叉负责系统的兴奋性，并且是“Ⅰ型”名称的基础。我们从大量实际锥体细胞的体外记录中验证了这种过渡的存在。得出诱发突发所需的电流脉冲的大小和持续时间之间的比例关系。我们还观察到这种类型的猝发兴奋性和多室模型中的比例关系，该模型由模拟感觉输入的现实随机突触输入驱动。最后，我们讨论了爆发性兴奋性与弱电鱼之间的交流的相关性。

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