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首页> 外文期刊>Journal of Computational Neuroscience >Neural network model of an amphibian ventilatory central pattern generator
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Neural network model of an amphibian ventilatory central pattern generator

机译：两栖透气中心模式发生器的神经网络模型

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The neuronal multiunit model presented here is a formal model of the central pattern generator (CPG) of the amphibian ventilatory neural network, inspired by experimental data from Pelophylax ridibundus. The kernel of the CPG consists of three pacemakers and two follower neurons (buccal and lung respectively). This kernel is connected to a chain of excitatory and inhibitory neurons organized in loops. Simulations are performed with Izhikevich-type neurons. When driven by the buccal follower, the excitatory neurons transmit and reorganize the follower activity pattern along the chain, and when driven by the lung follower, the excitatory and inhibitory neurons of the chain fire in synchrony. The additive effects of synaptic inputs from the pacemakers on the buccal follower account for (1) the low frequency buccal rhythm, (2) the intra-burst high frequency oscillations, and (3) the episodic lung activity. Chemosensitivity to acidosis is implemented by an increase in the firing frequency of one of the pacemakers. This frequency increase leads to both a decrease in the buccal burst frequency and an increase in the lung episode frequency. The rhythmogenic properties of the model are robust against synaptic noise and pacemaker jitter. To validate the rhythm and pattern genesis of this formal CPG, neurograms were built from simulated motoneuron activity, and compared with experimental neurograms. The basic principles of our model account for several experimental observations, and we suggest that these principles may be generic for amphibian ventilation.
机译：这里呈现的神经元多单位模型是两栖通气神经网络的中央图案发生器（CpG）的正式模型，受到来自Pelophylax Ridibundus的实验数据的启发。 CPG的核心由三名起搏器和两个从动型神经元（分别为肺炎和肺）组成。该核与在环中组织的兴奋性和抑制性神经元链连接。用Izhikevich型神经元进行模拟。当由口腔追随器驱动时，兴奋性神经元沿着链式传递和重新组织从属轴的活动模式，并且当由肺部跟随器驱动时，连锁连锁机的兴奋性和抑制性神经元。从起搏器对颊腹部追随者占（1）低频颊节节奏，（2）突发的高频振荡，（3）突发的高频振荡，和（3）显肺活动。对酸中毒的化学敏感性通过增加起搏器的烧制频率的增加来实现。该频率增加导致颊突发频率的降低和肺集发频的增加。该模型的节奏性特性对突触噪声和起搏器抖动具有稳健。为了验证这种正式CPG的节奏和模式创世纪，神经图是由模拟的运动神经元活动构建的，并与实验神经图进行比较。我们模型账户的基本原则对于几种实验观察，我们建议这些原则可能是两栖动物通风的通用。

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